SCHEMBL15879474

SCHEMBL15879474

COC[C@@H]1CNC(=O)O1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5711100 1.00
SCHEMBL2366043 1.00
SCHEMBL9550079 0.83 LMNA (0.65)
SCHEMBL2518366 0.81 MAOA (0.40)
SCHEMBL2518363 0.81 MAOA (0.40)
SCHEMBL19341993 0.81 LMNA (0.58)
SCHEMBL19341994 0.81 LMNA (0.58)
SCHEMBL19341995 0.81 LMNA (0.58)
SCHEMBL13981360 0.79 LMNA (0.53)
SCHEMBL9213532 0.79 LMNA (0.53)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023230609-A1 HETEROCYCLIC PAD4 INHIBITORS CELGENE CORPORATION (US) 2023-11-30 WO disclosed
EP-3567030-B1 QUINAZOLINE COMPOUND FOR EGFR INHIBITION MEDSHINE DISCOVERY INC (CN) 2022-02-09 EP disclosed
US-11040984-B2 Quinazoline compound for EGFR inhibition MEDSHINE DISCOVERY INC. (CN) 2021-06-22 US disclosed
US-11040984-B2 Quinazoline compound for EGFR inhibition MEDSHINE DISCOVERY INC. (CN) 2021-06-22 US disclosed
US-20200190107-A1 QUINAZOLINE COMPOUND FOR EGFR INHIBITION MEDSHINE DISCOVERY INC. (CN) 2020-06-18 US disclosed
US-20200190107-A1 QUINAZOLINE COMPOUND FOR EGFR INHIBITION MEDSHINE DISCOVERY INC. (CN) 2020-06-18 US disclosed
EP-3567030-A1 QUINAZOLINE COMPOUND FOR EGFR INHIBITION Medshine Discovery Inc. (CN) 2019-11-13 EP disclosed
EP-3567030-A1 QUINAZOLINE COMPOUND FOR EGFR INHIBITION Medshine Discovery Inc. (CN) 2019-11-13 EP disclosed
WO-2018121758-A1 QUINAZOLINE COMPOUND FOR EGFR INHIBITION 南京明德新药研发股份有限公司 2018-07-05 WO disclosed
US-9839641-B2 Compounds and methods for treating bacterial infections ENTASIS THERAPEUTICS LIMITED (GB) 2017-12-12 US disclosed
WO-2017156181-A1 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF RAZE THERAPEUTICS, INC. (US) 2017-09-14 WO disclosed
US-20170128458-A1 COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS ENTASIS THERAPEUTICS INC. 2017-05-11 US disclosed
US-9540394-B2 Compounds and methods for treating bacterial infections ENTASIS THERAPEUTICS LIMITED (GB) 2017-01-10 US disclosed
US-20160130281-A1 COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS ENTASIS THERAPEUTICS INC. 2016-05-12 US disclosed
EP-2948461-A1 COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS Entasis Therapeutics Limited (GB) 2015-12-02 EP disclosed
US-9187495-B2 Compounds and methods for treating bacterial infections ENTASIS THERAPEUTICS LIMITED (GB) 2015-11-17 US disclosed
US-20150203513-A1 COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS ASTRAZENECA AB (SE) 2015-07-23 US disclosed
US-8889671-B2 Compounds and methods for treating bacterial infections ASTRAZENECA AB (SE) 2014-11-18 US disclosed
WO-2014114929-A1 COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS ASTRAZENECA AB (SE) 2014-07-31 WO disclosed
US-20140206677-A1 COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS ASTRAZENECA AB (SE) 2014-07-24 US disclosed