Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.43 |
| ▸ | HTR2A | P28223 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17376358 | 0.88 | HTR2C (0.61) | HTR2CHTR2A | |
| SCHEMBL29361990 | 0.82 | HPGD (0.45) | HTR2CHTR2AKMT2ADRD2 | |
| SCHEMBL23268487 | 0.78 | MEN1 (0.58) | HTR2CMEN1KMT2A | |
| SCHEMBL31172738 | 0.78 | MEN1 (0.58) | HTR2CMEN1KMT2A | |
| SCHEMBL12180448 | 0.78 | ACHE (0.54) | HTR2CHTR2AMEN1KMT2ADRD2 | |
| SCHEMBL3692141 | 0.78 | MEN1 (0.58) | HTR2CMEN1KMT2A | |
| SCHEMBL18123010 | 0.77 | HTR2C (0.43) | HTR2CHTR2AMEN1KMT2A | |
| SCHEMBL16957367 | 0.77 | HTR2C (0.43) | HTR2CHTR2AMEN1KMT2ADRD2 | |
| SCHEMBL16554269 | 0.77 | MAOB (0.53) | HTR2CHTR2AMEN1KMT2A | |
| SCHEMBL24595061 | 0.77 | HTR2C (0.47) | HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948442-B1 | PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2016-10-26 | — | — | EP | disclosed |
| US-8877741-B2 | Pyrrolidine derivatives, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| US-20140213568-A1 | Pyrrolidine derivatives, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213568-A1 | Pyrrolidine derivatives, pharmaceutical compositions and uses thereof | PEPD, PGA5, PYCR1 | HTR2C 2510/4885HTR2A 2639/4885MEN1 3370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.