PGA5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL7355315	0.47	6/20
SCHEMBL7320800	0.74	5/20
SCHEMBL7346803	0.55	5/20
SCHEMBL7317104	0.49	5/20
SCHEMBL7385524	0.49	5/20
SCHEMBL7272845	0.49	5/20
SCHEMBL7340387	0.49	5/20
SCHEMBL3148728	0.43	5/20
SCHEMBL7320803	0.56	4/20
SCHEMBL7268859	0.47	3/20
SCHEMBL7275525	0.47	3/20
SCHEMBL8681567	0.44	3/20
SCHEMBL7331287	0.58	2/20
SCHEMBL7265128	0.53	2/20
SCHEMBL6828558	0.52	2/20
SCHEMBL5013146	0.34	2/20
Tipranavir (SCHEMBL40629)	1.00	1/20
Tipranavir (SCHEMBL5414762)	1.00	1/20
Tipranavir (SCHEMBL6953675)	1.00	1/20
Tipranavir (SCHEMBL6957763)	1.00	1/20

Clinical trials — most relevant to PGA5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality	PHASE4	RECRUITING
Multi-dimensional Clinical and Pathophysiological Profiles of Patients With Functional Dyspepsia and Effect of Gut Microbiota Manipulation Using Rifaximin for Its Treatment	PHASE2	UNKNOWN
Fosamprenavir for Laryngopharyngeal Upper Airway Tissue Treatment and Enzyme Reduction	PHASE2	NOT_YET_RECRUITING
Validation of Aspiration Markers	PHASE1	WITHDRAWN
Validation of Aspiration Markers in Intubated Patients	PHASE1	WITHDRAWN
Antigenic Competition in HIV Preventive Vaccines	PHASE1	COMPLETED
Evaluating the Immune Response to a rAd5 HIV Vaccine Administered in Three Different Ways in Healthy, HIV-Uninfected Adults	PHASE1	COMPLETED
Assessing the Impacts of a UESAD on Laryngeal Symptoms and Salivary Pepsin	nan	COMPLETED
Use of Blood Biomarkers to Predict Gastric Cancer Risk	nan	COMPLETED
Epidemiology of Helicobacter Pylori Infection in Moscow	nan	UNKNOWN
The Value of TFF3 in Diagnosis of Gastric Cancer	nan	UNKNOWN
Individually Tailored Strategies for the Precision Prevention of Gastric Cancer and Colorectal Cancer in the Community	nan	ENROLLING_BY_INVITATION
Gastropanel for Gastric Atrophy and Cancer Risk Assessment	nan	UNKNOWN
Pepsin As A Biomarker For Aspiration	nan	COMPLETED
Diagnosis of Microaspiration in Intubated Critically Ill Patients: Pepsin vs 99m Technetium	nan	WITHDRAWN
Nasal Endoscopic Screening and Risk Assessment for Early Gastric Cancer	nan	UNKNOWN
The Research of Constructing a Risk Assessment Model for Gastric Cancer Based on Machine Learning	nan	UNKNOWN
Exploratory Study of Potential Pulmonary Aspiration Markers From Bronchoalveolar Lavage Fluid	nan	COMPLETED
A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD	nan	COMPLETED
Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study	nan	COMPLETED
Helicobacter Pylori Infection and Gastric Disease in Bhutan: First Community-Wide, Population-Based Study	nan	COMPLETED
The Changes of Ryodoraku and HRV After PPI Treatment in GERD Patients	nan	UNKNOWN
Effect of AN-PEP Enzyme on Gluten Digestion in Gluten Sensitive Individuals	nan	COMPLETED
The Effact of Helicobacter Hylori Eradication on the Development of Gastric Mucosa Pathology	nan	UNKNOWN
Study to Investigate the Efficacy of Digestive Enzymes on Inflammation After a Meal	nan	UNKNOWN
Efficacy of Reza Band for the Treatment of Laryngopharyngeal Reflux	nan	WITHDRAWN
Gastrin, Anti-helicobacter Pylori and Pepsinogen Diagnostic Accuracy Study	nan	NOT_YET_RECRUITING
Eosinophilic Oesophagitis Assessment With String Testing	nan	UNKNOWN
Symptom Evaluation After Cessation of a Proton Pump Inhibitor in Healthy Volunteers	nan	COMPLETED
Effect of AN-PEP Enzyme on Gluten Digestion	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PGA5 binder may also engage these)

Protein	Name	Similarity
P0DJD7	—	1.000	P0DJD7 →
P0DJD8	—	1.000	P0DJD8 →
P11489	—	1.000	P11489 →
P27677	—	1.000	P27677 →
P03954	—	1.000	P03954 →
Q9N2D4	—	0.999	Q9N2D4 →
P00792	—	0.996	P00792 →
P27822	—	0.995	P27822 →
P28712	—	0.994	P28712 →
P27678	—	0.993	P27678 →
P27821	—	0.992	P27821 →
P81497	—	0.992	P81497 →
P00791	—	0.992	P00791 →
Q9GMY6	—	0.992	Q9GMY6 →
P28713	—	0.991	P28713 →
P16476	—	0.990	P16476 →
Q9GMY8	—	0.989	Q9GMY8 →
Q9N2D3	—	0.986	Q9N2D3 →
P00793	—	0.985	P00793 →
Q9N2D2	—	0.985	Q9N2D2 →
Q9GMY7	—	0.984	Q9GMY7 →
Q9GMY2	—	0.983	Q9GMY2 →
PGC	Gastricsin	0.982	landscape →
Q689Z7	—	0.981	Q689Z7 →
CTSE	Cathepsin E	0.980	landscape →
Q9D7R7	—	0.979	Q9D7R7 →
P04073	—	0.978	P04073 →
P70269	—	0.977	P70269 →
Q64411	—	0.977	Q64411 →
Q800A0	—	0.976	Q800A0 →