Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1590718 | 0.91 | PTGER4 (0.45) | HTR1AADRA1AAKR1C3AKR1C2PTGS1 | |
| SCHEMBL1590405 | 0.91 | PTGER4 (0.36) | HTR1AADRA1AAKR1C3AKR1C2PTGS1 | |
| SCHEMBL1590807 | 0.90 | PTGER4 (0.39) | HTR1AADRA1AAKR1C3AKR1C2PTGS1 | |
| SCHEMBL1590179 | 0.87 | AKR1C3 (0.47) | HTR1AADRA1AAKR1C3AKR1C2PTGS1 | |
| SCHEMBL1590785 | 0.83 | AKR1C3 (0.37) | HTR1AADRA1AAKR1C3AKR1C2PTGS1 | |
| SCHEMBL1590264 | 0.83 | PTGER4 (0.42) | HTR1AADRA1AAKR1C3AKR1C2PTGS1 | |
| SCHEMBL1591198 | 0.81 | HTR1A (0.52) | HTR1AADRA1AAKR1C3AKR1C2PTGS1 | |
| SCHEMBL2428776 | 0.81 | AKR1C3 (0.42) | HTR1AADRA1AAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL1590313 | 0.80 | PTGER4 (0.36) | HTR1AADRA1AAKR1C3AKR1C2PTGS1 | |
| SCHEMBL1591043 | 0.80 | PTGER4 (0.47) | PTGER4KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207213-B2 | Benzoisoindole derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2012-06-26 | — | — | US | disclosed |
| US-8026270-B2 | Benzo [F] isoindoles as EP4 receptor agonists | GLAXO GROUP LIMITED (GB) | 2011-09-27 | — | — | US | disclosed |
| US-20110092561-A1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2011-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092561-A1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | OPRK1, OPRD1, OPRL1 | HTR1A 49/4885ADRA1A 54/4885AKR1C3 885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.