Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.58 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.57 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4155251 | 0.84 | CTNNB1 (0.68) | CTNNB1SCN8ASCN10ASLC6A2SLC6A4 | |
| SCHEMBL19858889 | 0.82 | SCN8A (0.57) | SCN8ASCN10ASLC6A2SLC6A4MAPK8 | |
| SCHEMBL5114309 | 0.81 | ALPL (0.49) | SCN8ASCN10ASLC6A2SLC6A4SMN1; SMN2 | |
| SCHEMBL32667941 | 0.81 | KDM4E (0.66) | CTNNB1SIRT2SIRT1PARP10KDM4E | |
| SCHEMBL27549107 | 0.79 | CTNNB1 (0.70) | CTNNB1SCN8ASCN10ASLC6A4SIRT2 | |
| Benzoic Acid SCHEMBL29186974 | 0.78 | FAAH (0.46) | CTNNB1SLC6A2SLC6A4MAPK8MAPK10 | |
| SCHEMBL6518415 | 0.78 | CHEK1 (0.49) | SLC6A2SLC6A4MAPK8MAPK10CCNC | |
| SCHEMBL9138435 | 0.76 | CTNNB1 (0.51) | CTNNB1SCN8ASCN10ASLC6A2SLC6A4 | |
| Trifluoroacetic Acid SCHEMBL5478809 | 0.76 | CTNNB1 (0.81) | CTNNB1SIRT2SIRT1SMN1; SMN2PARP10 | |
| SCHEMBL12505440 | 0.76 | CTNNB1 (0.65) | CTNNB1SIRT2SIRT1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738009-B2 | Pyridone amides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-08-11 | — | — | US | disclosed |
| US-20190248745-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2019-08-15 | — | — | US | disclosed |
| US-10087143-B2 | Pyridone amides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-10-02 | — | — | US | disclosed |
| US-20180016235-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2018-01-18 | — | — | US | disclosed |
| US-9758483-B2 | Pyridone amides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-09-12 | — | — | US | disclosed |
| US-20170037009-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2017-02-09 | — | — | US | disclosed |
| EP-2953931-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2015-12-16 | — | — | EP | disclosed |
| US-9051270-B2 | Pyridone amides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-06-09 | — | — | US | disclosed |
| WO-2014120808-A9 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PARMACEUTICALS INCORPORATED (US) | 2015-05-14 | — | — | WO | disclosed |
| WO-2014120808-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PARMACEUTICALS INCORPORATED (US) | 2014-08-07 | — | — | WO | disclosed |
| US-20140213616-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180016235-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | SCN5A, SCN1A, KCNJ2 | CTNNB1 3878/4885SCN8A 77/4885SCN10A 12/4885 |
| US-20140213616-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | SCN5A, SCN1A, KCNJ2 | CTNNB1 3878/4885SCN8A 77/4885SCN10A 12/4885 |
| US-10738009-B2 | Pyridone amides as modulators of sodium channels | SCN5A, SCN1A, KCNJ2 | CTNNB1 3878/4885SCN8A 77/4885SCN10A 12/4885 |
| US-20170037009-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | SCN5A, SCN1A, KCNJ2 | CTNNB1 3878/4885SCN8A 77/4885SCN10A 12/4885 |
| US-10087143-B2 | Pyridone amides as modulators of sodium channels | SCN5A, SCN1A, KCNJ2 | CTNNB1 3878/4885SCN8A 77/4885SCN10A 12/4885 |
| US-20190248745-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | SCN5A, SCN1A, KCNJ2 | CTNNB1 3878/4885SCN8A 77/4885SCN10A 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.