Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15901905 | 0.85 | SORT1 (0.57) | SORT1ALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL28921272 | 0.83 | SORT1 (0.55) | SORT1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL15901600 | 0.83 | SORT1 (0.78) | SORT1GPR27SCN10AHDAC4HDAC6 | |
| SCHEMBL15901610 | 0.82 | KMT2A (0.54) | SORT1ALDH1A1SMN1; SMN2KMT2AGAA | |
| SCHEMBL15902053 | 0.81 | SORT1 (0.65) | SORT1SCN10AKCNK3KCNK9HDAC4 | |
| SCHEMBL15902067 | 0.81 | SORT1 (0.55) | SORT1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL15902028 | 0.80 | SORT1 (0.57) | SORT1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL15902152 | 0.79 | SORT1 (0.56) | SORT1ALDH1A1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL24669404 | 0.78 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KMT2ALMNAGAA | |
| SCHEMBL27463945 | 0.78 | KCNK3 (0.66) | ALDH1A1SMN1; SMN2KMT2ALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3459958-B1 | PROCESS AND INTERMEDIATES FOR PREPARING PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2024-08-07 | — | — | EP | disclosed |
| CN-114437062-B | Compound capable of being used as sodium channel regulator and application thereof | 成都海博为药业有限公司 | 2024-05-17 | — | — | CN | disclosed |
| US-11773119-B2 | Prodrugs of pyridone amides useful as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-03 | — | — | US | disclosed |
| US-11673864-B2 | Pyridone amides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-06-13 | — | — | US | disclosed |
| CN-114437062-A | Compound capable of being used as sodium channel regulator and application thereof | 成都海博为药业有限公司 | 2022-05-06 | — | — | CN | disclosed |
| EP-3865475-A1 | PROCESS FOR PREPARING PYRIDONE AMIDES WHICH ARE MODULATORS OF SODIUM CHANNELS AND INTERMEDIATE COMPOUNDS USED THEREIN | Vertex Pharmaceuticals Incorporated (US) | 2021-08-18 | — | — | EP | disclosed |
| CN-108395452-B | Prodrugs of pyridone amides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2021-08-03 | — | — | CN | disclosed |
| CN-108164457-B | Pyridone amides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2021-07-09 | — | — | CN | disclosed |
| US-20210047271-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC | 2021-02-18 | — | — | US | disclosed |
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |
| US-20160009743-A1 | PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC | 2016-01-14 | — | — | US | disclosed |
| EP-2953931-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2015-12-16 | — | — | EP | disclosed |
| US-9163042-B2 | Prodrugs of pyridone amides useful as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-10-20 | — | — | US | disclosed |
| US-20150246028-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2015-09-03 | — | — | US | disclosed |
| WO-2015089361-A1 | PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-06-18 | — | — | WO | disclosed |
| US-20150166589-A1 | PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2015-06-18 | — | — | US | disclosed |
| US-9051270-B2 | Pyridone amides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-06-09 | — | — | US | disclosed |
| WO-2014120808-A9 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PARMACEUTICALS INCORPORATED (US) | 2015-05-14 | — | — | WO | disclosed |
| WO-2014120808-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PARMACEUTICALS INCORPORATED (US) | 2014-08-07 | — | — | WO | disclosed |
| US-20140213616-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246028-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | SCN5A, SCN1A, KCNJ2 | SORT1 4300/4885ALDH1A1 1133/4885SMN1; SMN2 472/4885 |
| US-20160009743-A1 | PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS | TRPV1, P2RY1, P2RX3 | SORT1 3691/4885ALDH1A1 886/4885SMN1; SMN2 604/4885 |
| US-20140213616-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | SCN5A, SCN1A, KCNJ2 | SORT1 4300/4885ALDH1A1 1133/4885SMN1; SMN2 472/4885 |
| US-20150166589-A1 | PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS | TRPV1, P2RY1, P2RX3 | SORT1 3691/4885ALDH1A1 886/4885SMN1; SMN2 604/4885 |
| US-11773119-B2 | Prodrugs of pyridone amides useful as modulators of sodium channels | TRPV1, P2RY1, P2RX3 | SORT1 3691/4885ALDH1A1 886/4885SMN1; SMN2 604/4885 |
| US-20210047271-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | SCN5A, SCN1A, KCNJ2 | SORT1 4300/4885ALDH1A1 1133/4885SMN1; SMN2 472/4885 |
| US-11673864-B2 | Pyridone amides as modulators of sodium channels | SCN5A, SCN1A, KCNJ2 | SORT1 4300/4885ALDH1A1 1133/4885SMN1; SMN2 472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.