Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | PNLIP | P16233 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14662607 | 0.88 | SOS1 (0.44) | ERN1PTGDR2PNLIPEPAS1TDP1 | |
| SCHEMBL15904298 | 0.86 | ERN1 (0.47) | ERN1EPAS1LMNAHTR2ASLC6A4 | |
| SCHEMBL14662075 | 0.85 | ALDH1A1 (0.42) | ERN1EPAS1TDP1CYP1A2CYP3A4 | |
| SCHEMBL15904100 | 0.84 | ERN1 (0.42) | ERN1EPAS1TDP1LMNACYP1A2 | |
| SCHEMBL14662732 | 0.82 | ERN1 (0.48) | ERN1EPAS1 | |
| SCHEMBL15904179 | 0.80 | PPARG (0.43) | ERN1CYP1A2CYP3A4CYP2C9PPARG | |
| SCHEMBL31276674 | 0.79 | PLA2G7 (0.44) | PPARG | |
| SCHEMBL15904561 | 0.79 | HSD17B10 (0.45) | PTGDR2LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5175967 | 0.77 | SOS1 (0.44) | ERN1TDP1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL24512757 | 0.76 | TDP1 (0.44) | ERN1TDP1SMN1; SMN2POLBCASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948456-A1 | BICYCLIC PYRIMIDONE COMPOUNDS AS INHIBITORS OF LP-PLA2 | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2015-12-02 | — | — | EP | disclosed |
| WO-2014114249-A1 | BICYCLIC PYRIMIDONE COMPOUNDS AS INHIBITORS OF LP-PLA2 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-07-31 | — | — | WO | disclosed |