Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 3/20 | 0.48 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.48 |
| ▸ | GSK3A | P49840 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17840915 | 0.77 | TGFBR1 (0.53) | GSK3B | |
| SCHEMBL15058354 | 0.73 | KDM4E (0.72) | CCNB2CDK1CCNB1CCNB3PDGFRB | |
| SCHEMBL16729146 | 0.73 | AXL (0.44) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL21812461 | 0.71 | CYP11B1 (0.56) | CDK5CDK5R1KDM4EMAPTMEN1 | |
| SCHEMBL2289799 | 0.71 | DAO (0.47) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL21643937 | 0.70 | NPC1 (0.54) | GSK3AGSK3BPDGFRBPDGFRAKDM4E | |
| SCHEMBL15904794 | 0.70 | NTRK1 (0.48) | GSK3BCDK5CDK5R1MAPK1HSD17B10 | |
| SCHEMBL1374700 | 0.69 | MMP12 (0.47) | KDM4EALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL25723819 | 0.69 | CYP1A2 (0.38) | KDM4EMAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL4782250 | 0.69 | KDM4E (0.63) | CCNB2CDK1CCNB1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014115071-A1 | KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-07-31 | — | — | WO | claimed |
| WO-2014115071-A1 | KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-07-31 | — | — | WO | disclosed |