Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 14/20 | 0.51 |
| ▸ | CTSB | P07858 | 11/20 | 0.51 |
| ▸ | CTSK | P43235 | 10/20 | 0.51 |
| ▸ | CTSS | P25774 | 8/20 | 0.51 |
| ▸ | CTSF | Q9UBX1 | 3/20 | 0.43 |
| ▸ | GRN | P28799 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2156721 | 0.92 | CTSL (0.55) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL3767672 | 0.92 | CTSL (0.55) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL2929115 | 0.92 | CTSL (0.55) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL6092682 | 0.87 | CTSL (0.55) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL14579995 | 0.81 | CTSL (0.53) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL13624177 | 0.81 | CTSL (0.53) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL5395043 | 0.80 | CTSL (0.52) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL2155289 | 0.79 | CTSL (0.55) | CTSLCTSBCTSKCTSSGRN | |
| SCHEMBL4678049 | 0.79 | CTSL (0.55) | CTSLCTSBCTSKCTSSGRN | |
| SCHEMBL4419936 | 0.79 | CTSL (0.61) | CTSLCTSBCTSKCTSSGRN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791162-B2 | Cathepsin cysteine protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-07-29 | — | — | US | disclosed |