Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 11/20 | 0.55 |
| ▸ | CTSB | P07858 | 11/20 | 0.55 |
| ▸ | CTSK | P43235 | 11/20 | 0.55 |
| ▸ | CTSS | P25774 | 6/20 | 0.55 |
| ▸ | CTSF | Q9UBX1 | 4/20 | 0.49 |
| ▸ | GRN | P28799 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3767672 | 1.00 | CTSL (0.55) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL2156721 | 1.00 | CTSL (0.55) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL15905685 | 0.92 | CTSL (0.51) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL6092682 | 0.92 | CTSL (0.55) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL14579995 | 0.88 | CTSL (0.53) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL13624177 | 0.88 | CTSL (0.53) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL5395043 | 0.87 | CTSL (0.52) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL16377148 | 0.85 | CTSK (0.49) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL17585395 | 0.84 | CTSB (0.57) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL1169219 | 0.83 | CTSL (0.72) | CTSLCTSBCTSKCTSSGRN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225196-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | Merck Frosst Canada Ltd. (CA) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009067797-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | MERCK FROSST CANADA LTD. (CA) | 2009-06-04 | — | — | WO | disclosed |
| EP-1660436-A4 | CATHEPSIN INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2006-11-22 | — | — | EP | disclosed |
| EP-1660436-A1 | CATHEPSIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005021487-A1 | CATHEPSIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2005-03-10 | — | — | WO | disclosed |