SCHEMBL15906323

SCHEMBL15906323

Cc1nc2c(N)ncnc2n1C1OC(CO)[C@H](O)[C@@H]1O

nearest known ligand 0.80

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HSPA8 P11142 3/20 0.80
HSPA5 P11021 2/20 0.80
AMD1 P17707 4/20 0.77
RXFP1 Q9HBX9 1/20 0.76
GAPDH P04406 2/20 0.72
HSD17B10 Q99714 1/20 0.72
LMNA P02545 1/20 0.68
TP53 P04637 1/20 0.68
HBB P68871 1/20 0.68
SMN1; SMN2 Q16637 1/20 0.68
SLC28A2 O43868 2/20 0.67
ADORA3 P0DMS8 2/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL967124 1.00 HSPA8 (0.80) HSPA8HSPA5AMD1RXFP1GAPDH
SCHEMBL16805420 1.00 HSPA8 (0.80) HSPA8HSPA5AMD1RXFP1GAPDH
SCHEMBL15906300 1.00 HSPA8 (0.80) HSPA8HSPA5AMD1RXFP1GAPDH
SCHEMBL967122 1.00 HSPA8 (0.80) HSPA8HSPA5AMD1RXFP1GAPDH
SCHEMBL1135195 1.00 HSPA8 (0.80) HSPA8HSPA5AMD1RXFP1GAPDH
SCHEMBL18858928 1.00 HSPA8 (0.80) HSPA8HSPA5AMD1RXFP1GAPDH
SCHEMBL21283085 0.91 AMD1 (0.67) HSPA8HSPA5AMD1RXFP1GAPDH
SCHEMBL16378774 0.90 AMD1 (0.77) HSPA8HSPA5AMD1RXFP1GAPDH
SCHEMBL952452 0.89 AMD1 (0.76) HSPA8HSPA5AMD1RXFP1GAPDH
SCHEMBL952454 0.89 AMD1 (0.76) HSPA8HSPA5AMD1RXFP1GAPDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1765844-B1 PURINE NUCLEOTIDE DERIVATIVES SOLVELL AS (NO) 2014-07-30 EP disclosed