SCHEMBL15906347

SCHEMBL15906347

CNC(=O)c1cc(C#N)cc(I)c1NC(=O)c1cc(Cl)nn1-c1ncccc1Cl

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.36
MALT1 Q9UDY8 2/20 0.35
GRM4 Q14833 2/20 0.34
PKM P14618 1/20 0.34
DHODH Q02127 2/20 0.33
KCNH2 Q12809 4/20 0.33
GCK P35557 3/20 0.33
PPARG P37231 1/20 0.33
PDE10A Q9Y233 1/20 0.32
TRPV1 Q8NER1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15906336 0.92 PKM (0.35) KMT2AMALT1GRM4PKM
SCHEMBL959805 0.92 KMT2A (0.36) KMT2AMALT1GRM4PKMDHODH
SCHEMBL30845280 0.90 KMT2A (0.36) KMT2AMALT1PKMDHODHKCNH2
SCHEMBL15906349 0.90 KMT2A (0.35) KMT2AMALT1GRM4PKMDHODH
SCHEMBL563502 0.90 KMT2A (0.36) KMT2AMALT1PKMDHODHKCNH2
SCHEMBL15906348 0.89 KLKB1 (0.37) KMT2ATRPV1
SCHEMBL15906335 0.88 NTRK1 (0.40) KMT2AMALT1
SCHEMBL13442911 0.86 PKM (0.35) KMT2AMALT1PKMDHODHKCNH2
SCHEMBL10140237 0.85 KMT2A (0.36) KMT2AGRM4PKMDHODHKCNH2
SCHEMBL13239852 0.83 KMT2A (0.35) KMT2AMALT1PKMDHODHKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2759200-A1 Active agent combinations with insecticide properties Bayer CropScience AG (DE) 2014-07-30 EP disclosed