Sugi Predict

Sugi Predict / Compounds / SCHEMBL10140237

SCHEMBL10140237

SCHEMBL10140237

CNC(=O)c1cc(C#N)cc(C)c1NC(=O)c1cc(Cl)nn1-c1ncccc1C

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 1/20 0.36
▸ PKM P14618 1/20 0.36
▸ SLC2A1 P11166 1/20 0.34
▸ SLC2A2 P11168 1/20 0.34
▸ SLC2A3 P11169 1/20 0.34
▸ SLC2A4 P14672 1/20 0.34
▸ XIAP P98170 1/20 0.33
▸ BIRC2 Q13490 1/20 0.33
▸ JAK1 P23458 2/20 0.33
▸ TYK2 P29597 2/20 0.33
▸ JAK2 O60674 1/20 0.33
▸ JAK3 P52333 1/20 0.33
▸ PDE4A P27815 1/20 0.33
▸ PDE4B Q07343 1/20 0.33
▸ PDE4C Q08493 1/20 0.33
▸ PDE4D Q08499 1/20 0.33
▸ RIPK1 Q13546 1/20 0.33
▸ TRPV1 Q8NER1 1/20 0.32
▸ STAT3 P40763 1/20 0.32
▸ KCNH2 Q12809 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL563502 0.95 KMT2A (0.36) KMT2APKMSLC2A1SLC2A2SLC2A3
SCHEMBL30845280 0.95 KMT2A (0.36) KMT2APKMSLC2A1SLC2A2SLC2A3
SCHEMBL13442911 0.94 PKM (0.35) KMT2APKMSLC2A1SLC2A2SLC2A3
SCHEMBL11893158 0.92 SLC2A1 (0.35) KMT2APKMSLC2A1SLC2A2SLC2A3
SCHEMBL10140240 0.91 KMT2A (0.35) KMT2APKMSLC2A1SLC2A2SLC2A3
SCHEMBL13913221 0.89 PKM (0.36) KMT2APKMSLC2A1SLC2A2SLC2A3
SCHEMBL10140229 0.89 DHODH (0.37) KMT2APKMSLC2A1SLC2A2SLC2A3
SCHEMBL10140188 0.88 RAB9A (0.38) KMT2ATRPV1GRM4PPARG
SCHEMBL12956899 0.88 PKM (0.42) KMT2APKMSLC2A1SLC2A2SLC2A3
SCHEMBL959805 0.87 KMT2A (0.36) KMT2APKMTYK2PDE4APDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9949482-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2018-04-24 — — US disclosed
US-20170071205-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2017-03-16 — — US disclosed
US-20160302414-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION LLC (US) 2016-10-20 — — US disclosed
US-9282743-B2 Chemical compounds SYNGENTA PARTICIPATIONS AG (CH) 2016-03-15 — — US disclosed
US-9096525-B2 Iminipyridine derivatives and their uses as microbiocides SYNGENTA CROP PROTECTION, LLC (US) 2015-08-04 — — US disclosed
US-20140148339-A1 CHEMICAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2014-05-29 — — US disclosed
US-8536089-B2 For controlling phytopathogenic diseases; synergistic SYNGENTA CROP PROTECTION LLC (US) 2013-09-17 — — US disclosed
US-20130210625-A1 SPIROHETEROCYCLIC PYRROLIDINE DERIVATIVES BASED PESTICIDES SYNGENTA CROP PROTECTION LLC (US) 2013-08-15 — — US disclosed
US-20120309812-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION LLC (US) 2012-12-06 — — US disclosed
US-8124567-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, INC. (US) 2012-02-28 — — US disclosed
US-8124566-B2 Synergistic fungicidal compositions SYNGENTA CROP PROTECTION, INC. (US) 2012-02-28 — — US disclosed
US-20090149506-A1 INSECTICIDAL COMPOSITIONS WITH IMPROVED EFFECT BAYER CROPSCIENCE AG (DE) 2009-06-11 — — US disclosed
US-20080076664-A1 Fungicidal Compositions SYNGENTA CROP PROTECTION, INC. 2008-03-27 — — US disclosed
US-20080070785-A1 For controlling phytopathogenic diseases; synergistic SYNGENTA CROP PROTECTION, INC. (US) 2008-03-20 — — US disclosed
US-20070265267-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, INC. (US) 2007-11-15 — — US disclosed
US-20070244121-A1 Synergistic Fungicidal Compositions SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090149506-A1 INSECTICIDAL COMPOSITIONS WITH IMPROVED EFFECT PTEN, PPA1, NAAA KMT2A 1949/4885PKM 2171/4885SLC2A1 1104/4885
US-20120309812-A1 INSECTICIDAL COMPOUNDS ACHE, AADAC, NISCH KMT2A 1531/4885PKM 2393/4885SLC2A1 4746/4885
US-20130210625-A1 SPIROHETEROCYCLIC PYRROLIDINE DERIVATIVES BASED PESTICIDES DDT, PYCR1, PKD2 KMT2A 3529/4885PKM 1314/4885SLC2A1 4741/4885
US-20160302414-A1 INSECTICIDAL COMPOUNDS ACHE, AADAC, CASP3 KMT2A 3045/4885PKM 2201/4885SLC2A1 4777/4885
US-20070265267-A1 FUNGICIDAL COMPOSITIONS CRY1, ERG28, DDT KMT2A 1397/4885PKM 187/4885SLC2A1 1275/4885
US-20070244121-A1 Synergistic Fungicidal Compositions DDT, CRY1, HCN1 KMT2A 2009/4885PKM 174/4885SLC2A1 1324/4885
US-20080070785-A1 For controlling phytopathogenic diseases; synergistic BROX, EPM2A, MANBA KMT2A 3493/4885PKM 522/4885SLC2A1 3645/4885
US-20140148339-A1 CHEMICAL COMPOUNDS DDT, CYP1B1, CYP1A1 KMT2A 1487/4885PKM 1803/4885SLC2A1 1634/4885
US-20170071205-A1 FUNGICIDAL COMPOSITIONS PIK3C3, CYP51A1, CYP1B1 KMT2A 2404/4885PKM 1154/4885SLC2A1 4040/4885
US-20080076664-A1 Fungicidal Compositions AKR7A2, CYP51A1, TUBA3C KMT2A 3265/4885PKM 645/4885SLC2A1 2007/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.