Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARF6 | P62330 | 9/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 2/20 | 0.37 |
| ▸ | PSD | A5PKW4 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15909132 | 0.88 | ARF6 (0.36) | ARF6KDM4ELMNAMAPTHTT | |
| SCHEMBL15909027 | 0.87 | POLB (0.41) | ARF6LMNAMAPTTDP1 | |
| SCHEMBL1614861 | 0.87 | ARF6 (0.39) | ARF6MAPTNPSR1PLATESR1 | |
| SCHEMBL1614869 | 0.84 | MAPT (0.38) | KDM4ELMNAMAPTNPSR1PLAT | |
| SCHEMBL15908924 | 0.84 | ARF6 (0.42) | ARF6KDM4ELMNANPSR1PLAT | |
| SCHEMBL15926320 | 0.82 | PLAT (0.43) | ARF6KDM4EMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL1279349 | 0.81 | MEN1 (0.43) | ARF6KDM4ELMNAMAPTHTT | |
| SCHEMBL1279260 | 0.78 | ARF6 (0.45) | ARF6KDM4ELMNAMAPTHTT | |
| SCHEMBL13737418 | 0.75 | PLAT (0.41) | KDM4ELMNAMAPTSMN1; SMN2PLAT | |
| SCHEMBL13516739 | 0.73 | KDM4E (0.48) | KDM4ELMNAMAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |