Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 6/20 | 0.43 |
| ▸ | MMP9 | P14780 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 7/20 | 0.42 |
| ▸ | CA1 | P00915 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL176806 | 0.85 | MMP9 (0.45) | L3MBTL1MMP2MMP9CA2CA1 | |
| SCHEMBL177021 | 0.81 | CA2 (0.49) | L3MBTL1MMP2MMP9CA2CA1 | |
| SCHEMBL176872 | 0.77 | CASR (0.51) | L3MBTL1MMP2MMP9CA2CA1 | |
| SCHEMBL2521890 | 0.77 | MMP9 (0.46) | L3MBTL1MMP2MMP9CA2CA1 | |
| SCHEMBL177108 | 0.76 | L3MBTL1 (0.45) | L3MBTL1MMP2MMP9CA2CA1 | |
| SCHEMBL176798 | 0.76 | CA2 (0.50) | L3MBTL1MMP2MMP9CA2CA1 | |
| SCHEMBL177076 | 0.75 | CASR (0.53) | L3MBTL1MMP2MMP9CA2CA1 | |
| SCHEMBL176825 | 0.74 | CA2 (0.47) | L3MBTL1MMP2MMP9CA2CA1 | |
| SCHEMBL14575670 | 0.74 | MMP9 (0.43) | L3MBTL1MMP2MMP9CA2CA1 | |
| SCHEMBL176845 | 0.74 | CA2 (0.51) | L3MBTL1MMP2MMP9CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2345636-B1 | CASR AGONIST | AJINOMOTO KK (JP) | 2016-03-30 | — | — | EP | disclosed |
| US-9174932-B2 | CaSR agonists | AJINOMOTO CO., INC. (JP) | 2015-11-03 | — | — | US | disclosed |
| US-8796485-B2 | CaSR agonists | AJINOMOTO CO., INC. (JP) | 2014-08-05 | — | — | US | disclosed |