Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 6/20 | 0.52 |
| ▸ | PTPRZ1 | P23471 | 2/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.33 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924703 | 0.88 | CXCR2 (0.64) | CXCR2PTPRZ1KCNK2KCNK10PTPN2 | |
| SCHEMBL27693236 | 0.83 | CXCR2 (0.53) | CXCR2PTPRZ1KCNK2KCNK10PTPN2 | |
| SCHEMBL485653 | 0.82 | CXCR2 (0.67) | CXCR2PTPRZ1KCNK2KCNK10PDE2A | |
| SCHEMBL485250 | 0.82 | CXCR2 (0.67) | CXCR2PTPRZ1KCNK2KCNK10ALDH1A1 | |
| SCHEMBL15911883 | 0.79 | CXCR2 (0.79) | CXCR2PTPRZ1KCNK2KCNK10PTPN2 | |
| SCHEMBL3925807 | 0.77 | CXCR2 (0.58) | CXCR2ALDH1A1GAAMAPT | |
| SCHEMBL23460976 | 0.77 | CXCR2 (0.49) | CXCR2PTPRZ1KCNK2KCNK10ALDH1A1 | |
| SCHEMBL15911885 | 0.77 | ALOX5 (0.45) | CXCR2ALDH1A1MAPTALOX5KDM4E | |
| SCHEMBL25548759 | 0.77 | CXCR2 (0.49) | CXCR2PTPRZ1KCNK2KCNK10ALDH1A1 | |
| SCHEMBL485837 | 0.76 | ALDH1A1 (0.48) | CXCR2ALDH1A1KDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040690-B1 | INHIBITORS OF CXCR2 | SANOFI SA (FR) | 2014-08-06 | — | — | EP | claimed |