Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 6/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 5/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL351393 | 0.94 | AKR1C1 (0.55) | CYP2C19AKR1C1AKR1C3AKR1C2AKR1B10 | |
| SCHEMBL9685778 | 0.87 | CYP2C19 (0.49) | CYP2C19AKR1C1AKR1C3AKR1C2AKR1B10 | |
| SCHEMBL1048151 | 0.86 | AKR1C1 (0.68) | CYP2C19AKR1C1CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL3485961 | 0.86 | AKR1C1 (0.62) | CYP2C19AKR1C1AKR1C3AKR1C2AKR1B10 | |
| SCHEMBL3821416 | 0.85 | AKR1C1 (0.66) | CYP2C19AKR1C1CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL2860893 | 0.85 | AKR1C1 (0.66) | CYP2C19AKR1C1CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL343062 | 0.84 | AKR1C1 (0.64) | CYP2C19AKR1C1AKR1C3AKR1C2AKR1B10 | |
| SCHEMBL11090558 | 0.81 | CYP2C19 (0.48) | CYP2C19AKR1C1AKR1C3AKR1C2AKR1B10 | |
| SCHEMBL6498800 | 0.81 | OPRM1 (0.53) | CYP2C19AKR1C1CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL16897539 | 0.81 | LMNA (0.60) | CYP2C19AKR1C1CYP2C9CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140213538-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. | 2014-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213538-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR5 | CYP2C19 4544/4885AKR1C1 1875/4885AKR1C3 1330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.