Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL351393 | 0.87 | AKR1C1 (0.55) | LMNAALDH1A1CYP2C19AKR1C1TSHR | |
| SCHEMBL3416397 | 0.84 | LMNA (0.55) | LMNAALDH1A1CYP2C19TSHRNPSR1 | |
| SCHEMBL1627580 | 0.83 | AKR1C1 (0.68) | LMNAALDH1A1CYP2C19AKR1C1TSHR | |
| SCHEMBL3485961 | 0.83 | AKR1C1 (0.62) | LMNAALDH1A1CYP2C19AKR1C1TSHR | |
| SCHEMBL1048151 | 0.83 | AKR1C1 (0.68) | ALDH1A1CYP2C19AKR1C1TSHRNPSR1 | |
| SCHEMBL15897259 | 0.82 | ALDH1A1 (0.49) | LMNAALDH1A1CYP2C19AKR1C1TSHR | |
| SCHEMBL166581 | 0.82 | APP (0.50) | LMNAALDH1A1CYP2C19AKR1C1TSHR | |
| SCHEMBL196949 | 0.82 | POLB (0.56) | LMNAALDH1A1CYP2C19AKR1C1TSHR | |
| SCHEMBL22090138 | 0.82 | HDAC1 (0.53) | LMNAALDH1A1CYP2C19AKR1C1TSHR | |
| SCHEMBL2325209 | 0.82 | HDAC1 (0.55) | LMNAALDH1A1CYP2C19AKR1C1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092239-B1 | ARYL SULTAM DERIVATIVES AS RORC MODULATORS | HOFFMANN LA ROCHE (CH) | 2019-10-02 | — | — | EP | disclosed |
| EP-3092239-B1 | ARYL SULTAM DERIVATIVES AS RORC MODULATORS | HOFFMANN LA ROCHE (CH) | 2019-10-02 | — | — | EP | disclosed |
| CN-105899507-B | Aryl sultam derivative as RORc regulator | 豪夫迈·罗氏有限公司 | 2019-06-07 | — | — | CN | disclosed |
| US-10131644-B2 | Aryl sultam derivatives as RORc modulators | GENENTECH, INC. (US) | 2018-11-20 | — | — | US | disclosed |
| US-20170137393-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170137393-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| EP-3092239-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | F. Hoffmann-La Roche AG (CH) | 2016-11-16 | — | — | EP | disclosed |
| CN-105899507-A | Aryl sultam derivatives as rorc modulators | 豪夫迈·罗氏有限公司 | 2016-08-24 | — | — | CN | disclosed |
| WO-2015104354-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-07-16 | — | — | WO | disclosed |
| WO-2015104354-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10131644-B2 | Aryl sultam derivatives as RORc modulators | RORC, RORB, RORA | LMNA 2201/4885ALDH1A1 577/4885CYP2C19 396/4885 |
| US-20170137393-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | RORC, RORB, RORA | LMNA 2201/4885ALDH1A1 577/4885CYP2C19 396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.