Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 8/20 | 0.44 |
| ▸ | LPL | P06858 | 7/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17474563 | 0.88 | DGAT1 (0.54) | DGAT1LIPGLPLEGFRMAPT | |
| SCHEMBL31748489 | 0.85 | DGAT1 (0.52) | DGAT1RXRARXRBRXRGLIPG | |
| SCHEMBL15884409 | 0.84 | EGFR (0.52) | DGAT1LIPGLPLEGFR | |
| SCHEMBL544572 | 0.84 | DGAT1 (0.51) | DGAT1RXRARXRBMRGPRX4LIPG | |
| SCHEMBL182480 | 0.84 | DGAT1 (0.51) | DGAT1LIPGLPLEGFRMAPK1 | |
| SCHEMBL3772449 | 0.84 | DGAT1 (0.48) | DGAT1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL30869582 | 0.84 | DGAT1 (0.48) | DGAT1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL3767677 | 0.83 | DGAT1 (0.52) | DGAT1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL31065363 | 0.83 | DGAT1 (0.47) | DGAT1RXRARXRBRXRGLIPG | |
| SCHEMBL3767557 | 0.83 | DGAT1 (0.47) | DGAT1RXRARXRBRXRGLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951169-B1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-08-28 | — | — | EP | disclosed |
| US-9926333-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-03-27 | — | — | US | disclosed |
| US-20170327514-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-16 | — | — | US | disclosed |
| US-9732093-B2 | FLAP modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-15 | — | — | US | disclosed |
| US-20150368270-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-24 | — | — | US | disclosed |
| US-20150252008-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-10 | — | — | US | disclosed |
| US-9073876-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-07 | — | — | US | disclosed |
| US-20140221310-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (US) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327514-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | DGAT1 3028/4885ALOX5AP 70/4885RXRA 1547/4885 |
| US-20140221310-A1 | FLAP MODULATORS | FEN1, PGF, PTGIS | DGAT1 2739/4885ALOX5AP 61/4885RXRA 1339/4885 |
| US-20150368270-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | DGAT1 3028/4885ALOX5AP 70/4885RXRA 1547/4885 |
| US-20150252008-A1 | FLAP MODULATORS | FEN1, PGF, PTGIS | DGAT1 2739/4885ALOX5AP 61/4885RXRA 1339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.