Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 4/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.57 |
| ▸ | PRKACG | P22612 | 3/20 | 0.57 |
| ▸ | PRKACB | P22694 | 3/20 | 0.57 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.57 |
| ▸ | PRKCG | P05129 | 2/20 | 0.57 |
| ▸ | PRKCB | P05771 | 2/20 | 0.57 |
| ▸ | PRKCA | P17252 | 2/20 | 0.57 |
| ▸ | PRKCH | P24723 | 2/20 | 0.57 |
| ▸ | PRKCI | P41743 | 2/20 | 0.57 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.57 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15917140 | 1.00 | PRKACA (0.57) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL15917030 | 1.00 | PRKACA (0.57) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL17303552 | 0.84 | PRKACA (0.58) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL18672672 | 0.82 | PRKACA (0.56) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL19287702 | 0.82 | PRKACA (0.56) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL21566684 | 0.81 | PRKACA (0.55) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL15915927 | 0.80 | ALOX5AP (0.52) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL15915925 | 0.80 | ALOX5AP (0.52) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL21124304 | 0.80 | ACHE (0.57) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL28257109 | 0.80 | PRKACA (0.54) | PRKACAPRKCDPRKD3PRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3495359-A1 | FLAP MODULATORS | Janssen Pharmaceutica NV (BE) | 2019-06-12 | — | — | EP | disclosed |
| EP-3070085-B1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-09 | — | — | EP | disclosed |
| EP-2951170-B1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-10-24 | — | — | EP | disclosed |
| US-9884878-B2 | FLAP modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-06 | — | — | US | disclosed |
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |
| EP-3070085-A1 | FLAP MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2016-09-21 | — | — | EP | disclosed |
| US-20150376212-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-31 | — | — | US | disclosed |
| EP-2951170-A2 | FLAP MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2015-12-09 | — | — | EP | disclosed |
| US-20150259357-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-17 | — | — | US | disclosed |
| US-9079866-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-14 | — | — | US | disclosed |
| US-20140221311-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (US) | 2014-08-07 | — | — | US | disclosed |
| WO-2014121055-A2 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376212-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | PRKACA 675/4885PRKCD 2533/4885PRKD3 459/4885 |
| US-20150259357-A1 | FLAP MODULATORS | PGF, FEN1, TBXA2R | PRKACA 400/4885PRKCD 2010/4885PRKD3 338/4885 |
| US-20140221311-A1 | FLAP MODULATORS | PGF, FEN1, TBXA2R | PRKACA 400/4885PRKCD 2010/4885PRKD3 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.