Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 4/20 | 0.58 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.58 |
| ▸ | PRKACG | P22612 | 3/20 | 0.58 |
| ▸ | PRKACB | P22694 | 3/20 | 0.58 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.58 |
| ▸ | PRKCG | P05129 | 2/20 | 0.58 |
| ▸ | PRKCB | P05771 | 2/20 | 0.58 |
| ▸ | PRKCA | P17252 | 2/20 | 0.58 |
| ▸ | PRKCH | P24723 | 2/20 | 0.58 |
| ▸ | PRKCI | P41743 | 2/20 | 0.58 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.58 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15917032 | 0.84 | PRKACA (0.57) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL15917030 | 0.84 | PRKACA (0.57) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL15917140 | 0.84 | PRKACA (0.57) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL19287702 | 0.83 | PRKACA (0.56) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL18672672 | 0.83 | PRKACA (0.56) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL21566684 | 0.82 | PRKACA (0.55) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL28257109 | 0.81 | PRKACA (0.54) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL21124304 | 0.81 | ACHE (0.57) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL5635569 | 0.81 | L3MBTL1 (0.58) | PRKACAPRKCDPRKD3PRKACGPRKACB | |
| SCHEMBL16442259 | 0.81 | L3MBTL1 (0.58) | PRKACAPRKCDPRKD3PRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935247-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2019-08-28 | — | — | EP | disclosed |
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |
| US-20170334861-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-11-23 | — | — | US | disclosed |
| US-9745291-B2 | PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof | Epizyme, Inc. (US) | 2017-08-29 | — | — | US | disclosed |
| US-20170210751-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-07-27 | — | — | US | disclosed |
| US-9604930-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150344434-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2015-12-03 | — | — | US | disclosed |
| US-20150344433-A1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | Epizyme, Inc. (US) | 2015-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344433-A1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | PRMT5, PRMT1, PRMT3 | PRKACA 1089/4885PRKCD 1040/4885PRKD3 611/4885 |
| US-20170334861-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT3 | PRKACA 1083/4885PRKCD 1192/4885PRKD3 658/4885 |
| US-20170210751-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT6 | PRKACA 1269/4885PRKCD 1140/4885PRKD3 463/4885 |
| US-20150344434-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT3 | PRKACA 1020/4885PRKCD 1111/4885PRKD3 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.