Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4278256 | 0.84 | NCF1 (0.50) | NCF1LOXL2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL263407 | 0.81 | LOXL2 (0.50) | NCF1LOXL2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL6665709 | 0.81 | LOXL2 (0.55) | NCF1LOXL2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL30964808 | 0.81 | NCF1 (0.52) | NCF1LOXL2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL8907421 | 0.81 | NCF1 (0.52) | NCF1LOXL2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL264120 | 0.81 | NCF1 (0.52) | NCF1LOXL2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL30238817 | 0.81 | NCF1 (0.52) | NCF1LOXL2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL13868218 | 0.81 | NCF1 (0.52) | NCF1LOXL2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL14122720 | 0.81 | NCF1 (0.52) | NCF1LOXL2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL14120837 | 0.81 | NCF1 (0.52) | NCF1LOXL2CYP2D6CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4089077-A1 | NOVEL QUINOLINE DERIVATIVES AND USES THEREOF | Istituto Europeo di Oncologia S.r.l. (IT) | 2022-11-16 | — | — | EP | disclosed |
| US-20110092488-A1 | Quninoline Methanol Compounds for the Treatment and Prevention of Parasitic Infections | DOW GEOFFREY | 2011-04-21 | — | — | US | disclosed |
| WO-2008060269-A2 | QUINOLINE METHANOL COMPOUNDS FOR THE TREATMENT AND PREVENTION OF PARASITIC INFECTIONS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2006108666-A1 | MEFLOQUINE, NELFINAVIR AND SAQUINAVIR AS NOVEL AGENTS FOR NEURODEGENERATIVE AND (NEURO-) INFLAMMATORY DISEASES | PROTEOSYS AG (DE) | 2006-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092488-A1 | Quninoline Methanol Compounds for the Treatment and Prevention of Parasitic Infections | MTX1, MTX2, NQO2 | NCF1 2699/4885LOXL2 2343/4885CYP2D6 478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.