Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9105782 | 0.75 | PPARD (0.34) | PLA2G7HDAC1HDAC6HDAC5ROCK2 | |
| SCHEMBL9105791 | 0.75 | PPARD (0.37) | PLA2G7HDAC1HDAC6HDAC5 | |
| SCHEMBL876409 | 0.75 | TTR (0.40) | PLA2G7ROCK2ROCK1 | |
| SCHEMBL15920581 | 0.73 | CCR5 (0.36) | CCR5 | |
| SCHEMBL9104846 | 0.73 | S1PR1 (0.36) | PLA2G7ROCK2ROCK1 | |
| SCHEMBL9892536 | 0.70 | S1PR1 (0.34) | PLA2G7ROCK2ROCK1 | |
| SCHEMBL15920575 | 0.68 | SLC22A12 (0.39) | PLA2G7 | |
| SCHEMBL876362 | 0.68 | ALDH1A1 (0.41) | — | |
| SCHEMBL9109526 | 0.68 | AR (0.33) | — | |
| SCHEMBL25000014 | 0.67 | ALOX5AP (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014114694-A1 | 2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-07-31 | — | — | WO | disclosed |