Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 10/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15920581 | 0.79 | CCR5 (0.36) | MAOBAOC3MAOA | |
| SCHEMBL15920452 | 0.78 | CYP11B1 (0.36) | SLC22A12AREPAS1SCN9APLA2G7 | |
| SCHEMBL9900995 | 0.75 | AR (0.55) | SLC22A12ARCNR1CNR2PLA2G7 | |
| SCHEMBL14656148 | 0.69 | AR (0.56) | SLC22A12ARPLA2G7 | |
| SCHEMBL15920451 | 0.68 | PLA2G7 (0.33) | PLA2G7 | |
| SCHEMBL14663528 | 0.68 | AR (0.55) | SLC22A12ARMAOBMAOAEPAS1 | |
| SCHEMBL14656177 | 0.68 | SLC22A12 (0.48) | SLC22A12AREPAS1PLA2G7 | |
| SCHEMBL523187 | 0.67 | CYP19A1 (0.53) | SLC22A12ARMAOBMAOACNR1 | |
| SCHEMBL15262648 | 0.67 | CNR1 (0.45) | SLC22A12CNR1CNR2PLA2G7 | |
| SCHEMBL9904993 | 0.66 | SLC22A12 (0.41) | SLC22A12CNR1CNR2PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014114694-A1 | 2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-07-31 | — | — | WO | disclosed |