Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | CA9 | Q16790 | 4/20 | 0.33 |
| ▸ | PREP | P48147 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | APAF1 | O14727 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28724031 | 0.74 | KDM4E (0.39) | CA12CA1CA9 | |
| SCHEMBL6830102 | 0.74 | MEN1 (0.34) | MEN1APAF1KMT2A | |
| SCHEMBL9541397 | 0.72 | LMNA (0.49) | MEN1KMT2A | |
| SCHEMBL19926312 | 0.70 | NPC1 (0.45) | ALOX5APFEN1PREPMEN1KMT2A | |
| SCHEMBL31241395 | 0.69 | CYP3A4 (0.50) | CA12CA1CA9MEN1KMT2A | |
| SCHEMBL400055 | 0.69 | CYP3A4 (0.50) | CA12CA1CA9MEN1KMT2A | |
| SCHEMBL25695215 | 0.69 | ALOX5AP (0.31) | ALOX5APFEN1 | |
| SCHEMBL30556213 | 0.68 | CA1 (0.38) | ALOX5APFEN1CA12CA1CA9 | |
| SCHEMBL31432466 | 0.68 | OGA (0.35) | — | |
| SCHEMBL22655276 | 0.68 | OGA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951185-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | Aptinyx Inc. (US) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014120800-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. (US) | 2014-08-07 | — | — | WO | disclosed |