Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 2/20 | 0.44 |
| ▸ | METAP1 | P53582 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxyquinoline SCHEMBL26921554 | 0.91 | METAP2 (0.58) | LMNASMN1; SMN2KDM4ERAB9ANPC1 | |
| SCHEMBL250695 | 0.82 | KDM4E (0.54) | LMNASMN1; SMN2KDM4ERAB9ANPC1 | |
| SCHEMBL25212734 | 0.80 | KDM4E (0.41) | LMNAKDM4ERAB9AUSP2MAPT | |
| SCHEMBL3464510 | 0.79 | MEN1 (0.50) | LMNASMN1; SMN2KDM4ERAB9AMEN1 | |
| SCHEMBL4151477 | 0.78 | RAB9A (0.49) | LMNASMN1; SMN2KDM4ERAB9ANPC1 | |
| SCHEMBL21225851 | 0.78 | MCHR1 (0.45) | — | |
| SCHEMBL1101316 | 0.77 | KDM4E (0.53) | LMNASMN1; SMN2KDM4ERAB9ANPC1 | |
| SCHEMBL6269386 | 0.77 | NFE2L2 (0.33) | LMNASMN1; SMN2MAPTGAAMAPK1 | |
| SCHEMBL15180209 | 0.76 | KMT2A (0.47) | LMNASMN1; SMN2KDM4ENPC1USP2 | |
| SCHEMBL18318478 | 0.76 | LMNA (0.44) | LMNASMN1; SMN2KDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109900-A1 | AZABICYCLIC SHP2 INHIBITORS | PROMIDIS S.R.L. (IT) | 2024-04-04 | — | — | US | disclosed |
| EP-4288431-A1 | AZABICYCLIC SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022167682-A1 | AZABICYCLIC SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2022-08-11 | — | — | WO | disclosed |
| US-9741944-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2017-08-22 | — | — | US | disclosed |
| US-20170012221-A1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2017-01-12 | — | — | US | disclosed |
| US-9409883-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2016-08-09 | — | — | US | disclosed |
| US-20120292571-A1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2012-11-22 | — | — | US | disclosed |
| WO-1993003719-A1 | ARYLALKYLETHER AND ARYLALKYLTHIOETHER INHIBITORS OF LIPOXYGENASE ENZYME ACTIVITY | ABBOTT LABORATORIES (US) | 1993-03-04 | — | — | WO | disclosed |
| US-5183818-A | Also for inhibiting leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1993-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109900-A1 | AZABICYCLIC SHP2 INHIBITORS | PTPN22, PTPN2, PTPN5 | LMNA 4847/4885SMN1; SMN2 4426/4885KDM4E 411/4885 |
| US-20120292571-A1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | EPCAM, SLC39A3, L1CAM | LMNA 2617/4885SMN1; SMN2 4287/4885KDM4E 2789/4885 |
| US-20170012221-A1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | EPCAM, SLC39A3, L1CAM | LMNA 2617/4885SMN1; SMN2 4287/4885KDM4E 2789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.