Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.60 |
| ▸ | METAP1 | P53582 | 3/20 | 0.60 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 2/20 | 0.36 |
| ▸ | IDH2 | P48735 | 1/20 | 0.36 |
| ▸ | CBFB | Q13951 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4924097 | 0.76 | METAP2 (1.00) | METAP2METAP1CBFBGAAKMT2A | |
| SCHEMBL13137746 | 0.73 | METAP2 (0.56) | METAP2METAP1NPY5RNR3C1 | |
| SCHEMBL7035590 | 0.72 | METAP1 (0.72) | METAP2METAP1NPY5R | |
| SCHEMBL29912895 | 0.72 | GABRA1 (0.41) | METAP2METAP1DGAT2GABRA1GABRG2 | |
| SCHEMBL27158228 | 0.72 | GABRA1 (0.41) | METAP2METAP1DGAT2GABRA1GABRG2 | |
| SCHEMBL680854 | 0.70 | METAP2 (0.65) | METAP2METAP1NPY5RPOLBGAA | |
| SCHEMBL2045300 | 0.70 | METAP1 (0.60) | METAP2METAP1NPY5R | |
| SCHEMBL183275 | 0.70 | METAP1 (0.60) | METAP2METAP1NPY5R | |
| SCHEMBL30885355 | 0.70 | IDH1 (0.53) | GABRA1GABRG2GABRB3GABRA3NOTUM | |
| SCHEMBL19384206 | 0.70 | NOTUM (0.46) | GABRA1GABRG2GABRB3GABRA3NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-A1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014120748-A1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-08-07 | — | — | WO | disclosed |