Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.41 |
| ▸ | IDH1 | O75874 | 7/20 | 0.38 |
| ▸ | IDH2 | P48735 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27158228 | 1.00 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA3DGAT2 | |
| SCHEMBL15922752 | 0.72 | METAP2 (0.60) | GABRA1GABRG2GABRB3GABRA3DGAT2 | |
| SCHEMBL29912896 | 0.71 | PI4KA (0.46) | ALDH1A1KMT2AMEN1HPGDSMN1; SMN2 | |
| SCHEMBL29202322 | 0.71 | PI4KA (0.46) | ALDH1A1KMT2AMEN1HPGDSMN1; SMN2 | |
| SCHEMBL29912851 | 0.69 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA3IDH1 | |
| SCHEMBL27157974 | 0.69 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA3IDH1 | |
| SCHEMBL29418961 | 0.69 | NOTUM (0.41) | GABRA1GABRG2GABRB3GABRA3DGAT2 | |
| SCHEMBL15094600 | 0.69 | NOTUM (0.41) | GABRA1GABRG2GABRB3GABRA3DGAT2 | |
| SCHEMBL15624402 | 0.67 | NOTUM (0.58) | GABRA1GABRG2GABRB3GABRA3IDH1 | |
| SCHEMBL30395354 | 0.67 | NOTUM (0.58) | GABRA1GABRG2GABRB3GABRA3IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329881-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | Vanqua Bio, Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| CN-117642404-A | Small molecule modulators of glucocerebrosidase activity and uses thereof | 凡况生化公司 | 2024-03-01 | — | — | CN | disclosed |
| WO-2022232383-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | VANQUA BIO, INC. (US) | 2022-11-03 | — | — | WO | disclosed |