Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | G6PD | P11413 | 3/20 | 0.60 |
| ▸ | SHBG | P04278 | 2/20 | 0.60 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.60 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.60 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25912305 | 1.00 | MAPK1 (0.65) | MAPK1ALDH1A1TP53MAPTGPBAR1 | |
| SCHEMBL1592433 | 1.00 | MAPK1 (0.65) | MAPK1ALDH1A1TP53MAPTGPBAR1 | |
| SCHEMBL25912454 | 1.00 | MAPK1 (0.65) | MAPK1ALDH1A1TP53MAPTGPBAR1 | |
| SCHEMBL13420481 | 1.00 | MAPK1 (0.65) | MAPK1ALDH1A1TP53MAPTGPBAR1 | |
| SCHEMBL13937154 | 1.00 | MAPK1 (0.65) | MAPK1ALDH1A1TP53MAPTGPBAR1 | |
| SCHEMBL25323084 | 1.00 | MAPK1 (0.65) | MAPK1ALDH1A1TP53MAPTGPBAR1 | |
| SCHEMBL3199417 | 1.00 | MAPK1 (0.65) | MAPK1ALDH1A1TP53MAPTGPBAR1 | |
| SCHEMBL13420800 | 1.00 | MAPK1 (0.65) | MAPK1ALDH1A1TP53MAPTGPBAR1 | |
| SCHEMBL5700572 | 0.89 | MAPK1 (0.70) | MAPK1ALDH1A1TP53MAPTGPBAR1 | |
| SCHEMBL5700574 | 0.89 | MAPK1 (0.70) | MAPK1ALDH1A1TP53MAPTGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10087211-B2 | Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties | RESEARCH TRIANGLE INSTITUTE (US) | 2018-10-02 | — | — | US | disclosed |
| US-20170051008-A1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | RESEARCH TRIANGLE INSTITUTE (US) | 2017-02-23 | — | — | US | disclosed |
| US-9518080-B2 | Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties | RESEARCH TRIANGLE INSTITUTE (US) | 2016-12-13 | — | — | US | disclosed |
| EP-2155204-B1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | RES TRIANGLE INST (US) | 2016-08-17 | — | — | EP | disclosed |
| US-8575375-B2 | Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties | RESEARCH TRIANGLE INSTITUTE (US) | 2013-11-05 | — | — | US | disclosed |
| US-20110092473-A1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | RESEARCH TRIANGLE INSTITUTE (US) | 2011-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170051008-A1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | GABRA2, GABRA1, GABRA4 | MAPK1 828/4885ALDH1A1 1437/4885TP53 3648/4885 |
| US-20110092473-A1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | GABRA2, GABRA1, GABRA4 | MAPK1 828/4885ALDH1A1 1437/4885TP53 3648/4885 |
| US-10087211-B2 | Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties | GABRA2, GABRA1, GABRA4 | MAPK1 828/4885ALDH1A1 1437/4885TP53 3648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.