Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL8391952 | 0.84 | — | — | |
| Guanidine SCHEMBL28034554 | 0.80 | — | — | |
| Guanidine SCHEMBL29983942 | 0.78 | — | — | |
| SCHEMBL16741 | 0.78 | — | — | |
| Guanidine SCHEMBL11330173 | 0.78 | — | — | |
| Guanidine SCHEMBL5613752 | 0.78 | — | — | |
| Guanidine SCHEMBL165720 | 0.78 | NOS2 (0.42) | — | |
| SCHEMBL3667891 | 0.78 | — | — | |
| Guanidine SCHEMBL2003 | 0.78 | — | — | |
| Guanidine SCHEMBL6306009 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951191-B1 | METHOD OF PREPARING OLIGOMERIC COMPOUNDS USING MODIFIED COUPLING PROTOCOLS | IONIS PHARMACEUTICALS INC (US) | 2018-10-17 | — | — | EP | disclosed |
| US-9701708-B2 | Method of preparing oligomeric compounds using modified coupling protocols | IONIS PHARMACEUTICALS, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-20150368288-A1 | METHOD OF PREPARING OLIGOMERIC COMPOUNDS USING MODIFIED COUPLING PROTOCOLS | ISIS PHARMACEUTICALS, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| EP-2951191-A2 | METHOD OF PREPARING OLIGOMERIC COMPOUNDS USING MODIFIED COUPLING PROTOCOLS | Isis Pharmaceuticals, Inc. (US) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014120861-A2 | METHOD OF PREPARING OLIGOMERIC COMPOUNDS USING MODIFIED COUPLING PROTOCOLS | ISIS PHARMACEUTICALS, INC. (US) | 2014-08-07 | — | — | WO | disclosed |