Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.55 |
| ▸ | FEN1 | P39748 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15924988 | 0.84 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL363351 | 0.81 | NPC1 (0.60) | GAAALDH1A1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL15924938 | 0.77 | L3MBTL1 (0.51) | ALOX5APFEN1GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL516891 | 0.77 | ALDH1A1 (0.82) | GAAALDH1A1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL23462319 | 0.76 | NPC1 (0.55) | GAAALDH1A1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL13162370 | 0.76 | NPC1 (0.74) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2771765 | 0.76 | CRBN (0.51) | ALOX5APFEN1GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL2771766 | 0.76 | CRBN (0.51) | ALOX5APFEN1GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL23462320 | 0.76 | NPC1 (0.55) | GAAALDH1A1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL13162623 | 0.76 | NPC1 (0.74) | GAAALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951170-A2 | FLAP MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2015-12-09 | — | — | EP | claimed |
| WO-2014121055-A2 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-07 | — | — | WO | claimed |