Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15925247 | 0.84 | DAO (0.39) | DAOBRAFNSD2CASP6PARP1 | |
| SCHEMBL14764399 | 0.80 | BRAF (0.45) | BRAFPARP1 | |
| SCHEMBL9909695 | 0.80 | BRAF (0.36) | DAOBRAFNSD2CASP6AURKA | |
| SCHEMBL1665498 | 0.77 | PARP1 (0.42) | PARP1 | |
| SCHEMBL4370028 | 0.75 | ADORA1 (0.41) | PARP1PARP14PARP11PARP2AURKA | |
| SCHEMBL12778304 | 0.74 | CCR1 (0.38) | AURKA | |
| SCHEMBL21620891 | 0.74 | NOS3 (0.41) | — | |
| SCHEMBL21620456 | 0.74 | CCNB2 (0.40) | — | |
| SCHEMBL8558723 | 0.74 | PSMD14 (0.38) | AURKA | |
| SCHEMBL7832083 | 0.74 | KDM4E (0.36) | PARP1PARP14PARP11PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-B1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2014-08-06 | — | — | EP | disclosed |