Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.50 |
| ▸ | HTR3A | P46098 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15925256 | 0.84 | ALDH1A1 (0.43) | ALDH1A1CYP1A2HSD17B10TSHRCLK4 | |
| SCHEMBL23333325 | 0.73 | CCR1 (0.40) | ALDH1A1CYP1A2 | |
| SCHEMBL14029975 | 0.69 | HRH4 (0.67) | HRH4HTR3AHRH3ALDH1A1CYP1A2 | |
| SCHEMBL23332993 | 0.67 | NOS2 (0.41) | — | |
| SCHEMBL12847495 | 0.67 | CCR1 (0.38) | — | |
| SCHEMBL14237709 | 0.67 | TLR9 (0.64) | HRH4HTR3ATLR9MET | |
| SCHEMBL14237703 | 0.67 | TLR9 (0.64) | HRH4HTR3ATLR9METALDH1A1 | |
| SCHEMBL27904291 | 0.67 | HRH4 (0.53) | HRH4HTR3AHRH3METALDH1A1 | |
| SCHEMBL606857 | 0.67 | HRH4 (1.00) | HRH4HTR3AHRH3METALDH1A1 | |
| SCHEMBL81828 | 0.67 | HTR3A (0.52) | HRH4HTR3AHRH3HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-B1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2014-08-06 | — | — | EP | disclosed |