Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | WDR5 | P61964 | 6/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168743 | 0.91 | CXCR3 (0.58) | CXCR3KCNH2GRM5WDR5GRIN2B | |
| SCHEMBL168793 | 0.86 | CXCR3 (0.60) | CXCR3KCNH2GRM5GRIN2BPOLB | |
| SCHEMBL3728380 | 0.83 | CXCR3 (0.56) | CXCR3KCNH2GRM5WDR5GRIN2B | |
| SCHEMBL167336 | 0.82 | CXCR3 (0.55) | CXCR3KCNH2GRM5GRIN2BPOLB | |
| SCHEMBL22965168 | 0.80 | CXCR3 (0.60) | CXCR3KCNH2GRIN2BPOLBCCR1 | |
| SCHEMBL3729567 | 0.80 | CXCR3 (0.74) | CXCR3KCNH2GRM5POLBLMNA | |
| SCHEMBL164590 | 0.79 | CXCR3 (0.52) | CXCR3KCNH2GRM5GRIN2BPOLB | |
| SCHEMBL178025 | 0.79 | CXCR3 (0.58) | CXCR3KCNH2GRIN2BPOLBCCR1 | |
| SCHEMBL178151 | 0.79 | ADRA1B (0.44) | GRM5WDR5GRIN2B | |
| SCHEMBL3742956 | 0.78 | CXCR3 (0.59) | CXCR3KCNH2GRIN2BCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424840-B1 | CXCR3 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2014-08-06 | — | — | EP | disclosed |