Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 4/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1614501 | 0.92 | PLAT (0.41) | PLATALOX5LMNAMAOBMAPT | |
| SCHEMBL15926313 | 0.81 | PPARG (0.39) | LMNAMAPTALDH1A1MMP1MMP12 | |
| SCHEMBL1279125 | 0.80 | PLAT (0.56) | PLATALDH1A1KDM4E | |
| SCHEMBL1614818 | 0.79 | GPR119 (0.41) | PLATLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL1279373 | 0.78 | PLAT (0.59) | PLATMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL15926264 | 0.77 | LMNA (0.37) | LMNAMAPTMMP1MMP12PPARG | |
| SCHEMBL1278479 | 0.75 | PLAT (0.53) | PLATLMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL1614661 | 0.75 | LMNA (0.36) | LMNAMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL1278684 | 0.75 | PLAT (0.56) | PLATMAPTALDH1A1KDM4E | |
| SCHEMBL1286584 | 0.74 | PLAT (0.56) | PLATALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |