Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | ARF6 | P62330 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1614818 | 0.90 | GPR119 (0.41) | PPARGPPARALMNAPDE2ARXRA | |
| SCHEMBL15926347 | 0.87 | ARF6 (0.41) | ARF6LMNAALDH1A1 | |
| SCHEMBL15926264 | 0.87 | LMNA (0.37) | PPARGPPARAARF6LMNAPDE2A | |
| SCHEMBL15908924 | 0.84 | ARF6 (0.42) | ARF6LMNAALDH1A1 | |
| SCHEMBL1278731 | 0.84 | PDE2A (0.44) | ARF6LMNAPDE2AALDH1A1 | |
| SCHEMBL15926337 | 0.81 | PLAT (0.47) | PPARGLMNAMAPTMMP1MMP12 | |
| SCHEMBL15908944 | 0.80 | HTT (0.39) | LMNAMAPTMMP1MMP12ALDH1A1 | |
| SCHEMBL15926362 | 0.80 | AR (0.37) | ARF6PDE2AMGLLALDH1A1 | |
| SCHEMBL1614661 | 0.79 | LMNA (0.36) | PPARGPPARALMNAMAPTALDH1A1 | |
| SCHEMBL1614501 | 0.77 | PLAT (0.41) | LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |