Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenyl Biguanide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenyl Biguanide SCHEMBL16702225 | 0.94 | GAA (0.48) | MAPTGAAGFERTP53TSHR | |
| Phenyl Biguanide SCHEMBL467623 | 0.92 | ALDH1A1 (0.50) | MAPTGAAGFERTP53TSHR | |
| Phenyl Biguanide SCHEMBL27966486 | 0.91 | HSD17B10 (0.52) | MAPTGAAGFERTP53TSHR | |
| Phenyl Biguanide SCHEMBL2721730 | 0.90 | ALDH1A1 (0.48) | MAPTGAAGFERTP53TSHR | |
| Phenyl Biguanide SCHEMBL28093786 | 0.90 | ALDH1A1 (0.48) | MAPTGAAGFERTP53TSHR | |
| Phenyl Biguanide SCHEMBL1989457 | 0.89 | ALDH1A1 (0.47) | MAPTGAAGFERTP53TSHR | |
| Phenyl Biguanide SCHEMBL28429189 | 0.87 | ACP1 (0.44) | MAPTGAAGFERTP53TSHR | |
| Phenyl Biguanide SCHEMBL9459112 | 0.87 | ALDH1A1 (0.45) | MAPTGAAGFERTP53TSHR | |
| SCHEMBL2955430 | 0.85 | GAA (0.55) | MAPTGAAGFERTP53TSHR | |
| Oxalic Acid SCHEMBL30876191 | 0.84 | SMN1; SMN2 (0.58) | MAPTGAAGFERTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115052737-A | Method for producing laminated structure, and composition set for inkjet | 积水化学工业株式会社 | 2022-09-13 | — | — | CN | disclosed |
| EP-2328719-B1 | ABRASIVE MATERIAL PRODUCT, ITS PRODUCTION METHOD AND USE METHOD | 3M INNOVATIVE PROPERTIES CO (US) | 2021-02-24 | — | — | EP | disclosed |
| CN-107109183-B | Adhesive for ink jet, method for manufacturing semiconductor device, and electronic component | 积水化学工业株式会社 | 2019-05-21 | — | — | CN | disclosed |
| US-9919406-B2 | Abrasive material product, its production method and use method | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2018-03-20 | — | — | US | disclosed |
| CN-107109139-A | Adhesive for ink jet, method for manufacturing semiconductor device, and electronic component | 积水化学工业株式会社 | 2017-08-29 | — | — | CN | disclosed |
| CN-107109183-A | Adhesive for ink jet, method for manufacturing semiconductor device, and electronic component | 积水化学工业株式会社 | 2017-08-29 | — | — | CN | disclosed |
| CN-102123830-B | Abrasive material product, its production method and use method | 3M INNOVATIVE PROPERTIES CO | 2015-03-18 | — | — | CN | disclosed |
| CN-102123830-A | Abrasive material product, its production method and use method | 3M INNOVATIVE PROPERTIES CO | 2011-07-13 | — | — | CN | disclosed |
| EP-2328719-A2 | ABRASIVE MATERIAL PRODUCT, ITS PRODUCTION METHOD AND USE METHOD | 3M Innovative Properties Company (US) | 2011-06-08 | — | — | EP | disclosed |
| US-20110092137-A1 | ABRASIVE MATERIAL PRODUCT, ITS PRODUCTION METHOD AND USE METHOD | 3M INNOVATIVE PROPERTIES COMPANY | 2011-04-21 | — | — | US | disclosed |
| WO-2010011801-A2 | ABRASIVE MATERIAL PRODUCT, ITS PRODUCTION METHOD AND USE METHOD | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2010-01-28 | — | — | WO | disclosed |
| US-6620764-B1 | An image receptor surface which receives an image of a sublimation dye thermally transferred thereto from a foundation sheet for formation of the image therein, the image receptor surface comprising a thermochromatic layer with | SAKURA COLOR PRODUCTS CORPORATION (JP) | 2003-09-16 | — | — | US | disclosed |
| US-6313067-B1 | TEMPERATURE SENSITIVE THERMOCHROMATIC LAYER BEING OPAQUE AT ONE TEMPERATURE AND TRANSPARENT AT ANOTHER, IMAGE LAYER IN CONTACT | SAKURA COLOR PRODUCTS CORPORATION (JP) | 2001-11-06 | — | — | US | disclosed |