Phenyl Biguanide

Phenyl Biguanide

SCHEMBL467623

N=C(N)NC(=N)Nc1ccccc1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
TAS2R38 P59533 3/20 0.50
HSD17B10 Q99714 3/20 0.50
TP53 P04637 2/20 0.50
TSHR P16473 2/20 0.50
TYR P14679 1/20 0.50
GAA P10253 4/20 0.44
KMT2A Q03164 3/20 0.44
MAPT P10636 2/20 0.44
GFER P55789 1/20 0.44
GRIN2D O15399 1/20 0.44
GRIN3B O60391 1/20 0.44
LMNA P02545 1/20 0.44
CYP2D6 P10635 1/20 0.44
SLC6A2 P23975 1/20 0.44
GRIN1 Q05586 1/20 0.44
GRIN2A Q12879 1/20 0.44
GRIN2B Q13224 1/20 0.44
GRIN2C Q14957 1/20 0.44
GRIN3A Q8TCU5 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenyl Biguanide SCHEMBL28093786 0.98 ALDH1A1 (0.48) ALDH1A1TAS2R38HSD17B10TP53TSHR
Phenyl Biguanide SCHEMBL2721730 0.98 ALDH1A1 (0.48) ALDH1A1TAS2R38HSD17B10TP53TSHR
Phenyl Biguanide SCHEMBL1989457 0.96 ALDH1A1 (0.47) ALDH1A1TAS2R38HSD17B10TP53TSHR
Phenyl Biguanide SCHEMBL16702225 0.94 GAA (0.48) ALDH1A1TAS2R38HSD17B10TP53TSHR
Phenyl Biguanide SCHEMBL9459112 0.94 ALDH1A1 (0.45) ALDH1A1TAS2R38HSD17B10TP53TSHR
Phenyl Biguanide SCHEMBL1592736 0.92 MAPT (0.47) ALDH1A1TAS2R38HSD17B10TP53TSHR
Phenyl Biguanide SCHEMBL28429189 0.91 ACP1 (0.44) ALDH1A1TAS2R38HSD17B10TP53TSHR
Phenyl Biguanide SCHEMBL27966486 0.91 HSD17B10 (0.52) ALDH1A1TAS2R38HSD17B10TP53TSHR
Phenyl Biguanide SCHEMBL28014085 0.91 ALDH1A1 (0.43) ALDH1A1TAS2R38HSD17B10TP53TSHR
SCHEMBL3068902 0.89 F2 (0.43) ALDH1A1TAS2R38HSD17B10TP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2108 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120022762-A Nanofiltration composite membrane and preparation method and application thereof 中国科学院大连化学物理研究所 2025-05-23 CN claimed
CN-119899941-A Lithium composite extractant and method for extracting lithium 中国科学院过程工程研究所 2025-04-29 CN claimed
CN-119816550-A Surface-functionalized material and use thereof 牛津大学(苏州)科技有限公司 2025-04-11 CN claimed
CN-116376229-B Epoxy resin for long-pot-life carbon fiber winding and preparation method thereof 四川东树新材料有限公司 2025-02-14 CN claimed
CN-119371776-A Epoxy resin system bulk molding compound and preparation method thereof 华东理工大学华昌聚合物有限公司 2025-01-28 CN claimed
CN-119015834-A Carbon dioxide separation membrane and preparation method thereof 国家能源投资集团有限责任公司 2024-11-26 CN claimed
CN-118787751-A Use of LSD1 inhibitors in combination with drugs for the treatment of cancer 中国科学院上海药物研究所 2024-10-18 CN claimed
WO-2024213057-A1 USE OF COMBINATION OF LSD1 INHIBITOR AND DRUG TO TREAT CANCER 中国科学院上海药物研究所 2024-10-17 WO claimed
US-20240252535-A1 CELLULAR COMPOSITION FOR TREATMENT OF DISEASES, DISORDERS OR CONDITIONS AND METHOD OF USE YZTHERAPEUTIC PERFORMANCE LTD. (IL) 2024-08-01 US claimed
CN-118141793-A Use of metformin and other guanidine-containing compounds to solubilize summer-lyone crystals and to alleviate inflammation in acute lung injury 中国医学科学院基础医学研究所 2024-06-07 CN claimed
EP-0608308-B1 ANTI-SEBORRHOEIC FORMULATION MASON KENNETH VINCENT (AU) 1999-08-04 EP claimed
US-5602277-A Substituted benzene derivatives useful as neuraminidase inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 1997-02-11 US claimed
WO-1996030329-A1 SUBSTITUTED BENZENE DERIVATIVES USEFUL AS NEURAMINIDASE INHIBITORS BIOCRYST PHARMACEUTICALS, INCORPORATED (US) 1996-10-03 WO claimed
WO-1995027761-A1 POWDER COMPOSITION FOR COATINGS MACHLIAKOVSKI LEONID NIKOLAYEV (RU) 1995-10-19 WO claimed
WO-1992007560-A1 BIGUANIDES AND DERIVATIVES THEREOF AS INHIBITORS OF ADVANCED GLYCOSYLATION OF A TARGET PROTEIN THE ROCKEFELLER UNIVERSITY (US) 1992-05-14 WO claimed
US-4959267-A COATING WITH CURED GUANIDE COMPOUND, CURED RESORCINOL-FORMALDEHYDE RESIN DU PONT CANADA INC. (CA) 1990-09-25 US claimed
US-4833204-A Epoxy resin composition for a copper-clad laminate HITACHI CHEMICAL COMPANY, LTD. (JP) 1989-05-23 US claimed
US-4797340-A Dry electrophotographic toner comprising graft copolymer FUJI XEROX CO., LTD. (JP) 1989-01-10 US claimed
EP-0297748-A2 Process for protecting articles from attack by bleaching solutions Du Pont Canada Inc. (CA) 1989-01-04 EP claimed
US-4232105-A PHENOL-MODIFIED DIAZO RESIN-WATER SOLUBLE ACRYLIC POLYMER LAYER; AMINO RESIN-POLYAMIDE-PIGMENT LAYER; DURABILITY OJI PAPER CO., LTD. (JP) 1980-11-04 US claimed