Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 6/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166833 | 0.86 | P2RX3 (0.45) | P2RX3P2RX2GAAMGAMSI | |
| SCHEMBL16383032 | 0.81 | MGAM (0.31) | P2RX3P2RX2GAAMGAMSI | |
| SCHEMBL15706596 | 0.81 | CYP1A2 (0.34) | P2RX3P2RX2GAAPOLBGFER | |
| SCHEMBL13085628 | 0.79 | P2RX3 (0.43) | P2RX3P2RX2GAA | |
| SCHEMBL10102822 | 0.78 | P2RX3 (0.36) | P2RX3P2RX2GAAMGAMSI | |
| SCHEMBL13085693 | 0.78 | TUBB1 (0.40) | P2RX3P2RX2GAAMGAMSI | |
| SCHEMBL29786811 | 0.77 | P2RX3 (0.38) | P2RX3P2RX2GAAMGAMSI | |
| SCHEMBL13059718 | 0.76 | GAA (0.48) | P2RX3P2RX2GAAMGAMSI | |
| SCHEMBL12190518 | 0.76 | P2RX3 (0.48) | P2RX3P2RX2GAAMGAMSI | |
| SCHEMBL21142303 | 0.76 | GAA (0.48) | P2RX3P2RX2GAAMGAMSI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160075724-A1 | CETP Inhibitors | MERCK SHARP & DOHME (US) | 2016-03-17 | — | — | US | disclosed |
| US-20140221383-A1 | CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221383-A1 | CETP INHIBITORS | CETP, APOB, MTTP | P2RX3 4449/4885P2RX2 4366/4885GAA 1732/4885 |
| US-20160075724-A1 | CETP Inhibitors | CETP, APOB, MTTP | P2RX3 4449/4885P2RX2 4366/4885GAA 1732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.