Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | VDAC2 | P45880 | 1/20 | 0.45 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4465299 | 0.86 | L3MBTL1 (0.79) | L3MBTL1HIF1AALDH1A1LMNAPKM | |
| SCHEMBL1592847 | 0.84 | ALDH1A1 (0.57) | L3MBTL1HIF1AKMT2AMEN1ALDH1A1 | |
| SCHEMBL12703782 | 0.83 | VDAC2 (0.53) | L3MBTL1HIF1AKMT2AMEN1EGFR | |
| SCHEMBL4400208 | 0.79 | HIF1A (0.71) | L3MBTL1HIF1AKMT2AMEN1ALDH1A1 | |
| SCHEMBL4507484 | 0.79 | L3MBTL1 (0.61) | L3MBTL1HIF1AALDH1A1LMNAPKM | |
| SCHEMBL4657219 | 0.77 | SLC7A11 (0.62) | HIF1AVDAC2SLC7A11 | |
| SCHEMBL12610306 | 0.77 | VDAC2 (0.61) | HIF1AKMT2AMEN1POLBHTR7 | |
| SCHEMBL14767392 | 0.77 | HIF1A (0.68) | L3MBTL1HIF1AKMT2AMEN1ALDH1A1 | |
| SCHEMBL14303441 | 0.77 | HIF1A (0.68) | L3MBTL1HIF1AKMT2AMEN1ALDH1A1 | |
| SCHEMBL13789634 | 0.77 | L3MBTL1 (0.58) | L3MBTL1HIF1AALDH1A1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575143-B2 | 3-aryl-substituted quinazolones, and uses thereof | PROLEXYS PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8575143-B2 | 3-aryl-substituted quinazolones, and uses thereof | PROLEXYS PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8575143-B2 | 3-aryl-substituted quinazolones, and uses thereof | PROLEXYS PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20110092489-A1 | 3-Aryl-Substituted Quinazolones, and Uses Thereof | Prolexys Pharmaceuticals ,Inc. (US) | 2011-04-21 | — | — | US | disclosed |
| US-20110092489-A1 | 3-Aryl-Substituted Quinazolones, and Uses Thereof | Prolexys Pharmaceuticals ,Inc. (US) | 2011-04-21 | — | — | US | disclosed |
| US-20110092489-A1 | 3-Aryl-Substituted Quinazolones, and Uses Thereof | Prolexys Pharmaceuticals ,Inc. (US) | 2011-04-21 | — | — | US | disclosed |
| EP-1999116-A2 | 3-ARYL-SUBSTITUTED QUINAZOLONES, AND USES THEREOF | Prolexys Pharmaceuticals, Inc. (US) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007076087-A2 | 3-ARYL-SUBSTITUTED QUINAZOLONES, AND USES THEREOF | PROLEXYS PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092489-A1 | 3-Aryl-Substituted Quinazolones, and Uses Thereof | MKI67, MCL1, HCCS | L3MBTL1 2892/4885HIF1A 1381/4885KMT2A 3005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.