Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Vosaroxin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vosaroxin SCHEMBL674441 | 1.00 | HTR3A (0.35) | HTR3AKMT2AALDH1A1PPARGMAPK10 | |
| Vosaroxin SCHEMBL3207291 | 1.00 | HTR3A (0.35) | HTR3AKMT2AALDH1A1PPARGMAPK10 | |
| Vosaroxin SCHEMBL195037 | 1.00 | HTR3A (0.35) | HTR3AKMT2AALDH1A1PPARGMAPK10 | |
| Vosaroxin SCHEMBL7824841 | 0.99 | HTR3A (0.35) | HTR3AKMT2AALDH1A1PPARGMAPK10 | |
| Vosaroxin SCHEMBL7824869 | 0.99 | HTR3A (0.35) | HTR3AKMT2AALDH1A1PPARGMAPK10 | |
| Vosaroxin SCHEMBL7824853 | 0.99 | HTR3A (0.35) | HTR3AKMT2AALDH1A1PPARGMAPK10 | |
| Vosaroxin SCHEMBL18694851 | 0.99 | HTR3A (0.35) | HTR3AKMT2AALDH1A1PPARGMAPK10 | |
| Vosaroxin SCHEMBL29914037 | 0.99 | HTR3A (0.35) | HTR3AKMT2AALDH1A1PPARGMAPK10 | |
| SCHEMBL15929815 | 0.94 | HTR3A (0.36) | HTR3AKMT2AALDH1A1PPARGMAPK10 | |
| SCHEMBL7836101 | 0.90 | ALDH1A1 (0.35) | HTR3AKMT2AALDH1A1PPARGMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040738-B2 | Intermediate compounds of tamiflu, methods of preparation and uses thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2015-05-26 | — | — | US | disclosed |
| US-20140221662-A1 | INTERMEDIATE COMPOUNDS OF TAMIFLU, METHODS OF PREPARATION AND USES THEREOF | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221662-A1 | INTERMEDIATE COMPOUNDS OF TAMIFLU, METHODS OF PREPARATION AND USES THEREOF | NNMT, FLT3, TPMT | HTR3A 543/4885KMT2A 1749/4885ALDH1A1 919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.