Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 11/20 | 0.33 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.33 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | CALCA | P06881 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | NEK2 | P51955 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29388502 | 0.86 | MAP3K11 (0.39) | MAP3K11RAMP1CALCRLMAPK14 | |
| SCHEMBL30748975 | 0.83 | MAP3K11 (0.46) | MAP3K11MAPK14 | |
| SCHEMBL30748859 | 0.83 | MAP3K11 (0.43) | MAP3K11MAPK14 | |
| SCHEMBL30749023 | 0.81 | MAP3K11 (0.45) | MAP3K11MAPK14 | |
| SCHEMBL13748469 | 0.80 | BACE1 (0.36) | MAP3K11CALCA | |
| SCHEMBL17525083 | 0.79 | CRBN (0.40) | — | |
| SCHEMBL15935948 | 0.77 | CHRM2 (0.36) | CYP1A2NEK2 | |
| SCHEMBL1700112 | 0.77 | CALCA (0.49) | METCALCRLCALCA | |
| SCHEMBL15935917 | 0.76 | KCNH2 (0.37) | — | |
| SCHEMBL261125 | 0.72 | CALCRL (0.36) | RAMP1CALCRLCALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796260-B2 | Imidazobenzazepine CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-08-05 | — | — | US | disclosed |