Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.44 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.44 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418753 | 0.86 | ALDH1A1 (0.71) | ALDH1A1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL4081642 | 0.83 | ALDH1A1 (1.00) | ALDH1A1KMT2ATDP1KDM4EPOLB | |
| SCHEMBL4261329 | 0.81 | SMN1; SMN2 (0.59) | ALDH1A1MAPTKMT2ATP53ALOX12 | |
| SCHEMBL10455040 | 0.81 | ALDH1A1 (0.61) | ALDH1A1NPC1MAPTRAB9ATP53 | |
| SCHEMBL15936185 | 0.80 | ALDH1A1 (0.47) | ALDH1A1KMT2ATP53LMNATDP1 | |
| SCHEMBL27825507 | 0.80 | ALDH1A1 (0.58) | ALDH1A1NPC1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL18861007 | 0.80 | SMN1; SMN2 (0.57) | ALDH1A1MAPTKMT2ATP53ALOX12 | |
| SCHEMBL711082 | 0.80 | ALDH1A1 (0.73) | ALDH1A1KMT2AKDM4EPOLBPARP10 | |
| SCHEMBL1316975 | 0.80 | ALDH1A1 (0.73) | ALDH1A1KMT2ATDP1CTSBKDM4E | |
| SCHEMBL28365983 | 0.80 | ALDH1A1 (0.73) | ALDH1A1MAPTKMT2ATDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953927-B1 | SUBSTITUTED BENZAMIDES WITH ACTIVITY TOWARDS EP4 RECEPTORS | DRACONIS PHARMA S L (ES) | 2016-11-16 | — | — | EP | disclosed |
| EP-2765128-A1 | Substituted benzamides with activity towards EP4 receptors | Almirall, S.A. (ES) | 2014-08-13 | — | — | EP | disclosed |