Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 12/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193176 | 0.88 | RAB9A (0.48) | PTGER4EHMT2ALDH1A1MAPTHDAC6 | |
| SCHEMBL1192902 | 0.88 | KDM4E (0.55) | PTGER4KDM4EEHMT2ALDH1A1RAB9A | |
| SCHEMBL1193171 | 0.84 | PTGER4 (0.51) | PTGER4 | |
| Aniline SCHEMBL15936198 | 0.82 | PTGER4 (0.50) | PTGER4KDM4E | |
| SCHEMBL1193107 | 0.74 | CNR2 (0.40) | PTGER4KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL1193104 | 0.74 | ALDH1A1 (0.40) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL1192756 | 0.69 | NTRK1 (0.36) | PTGER4KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL2100541 | 0.66 | KDM4E (0.55) | KDM4EMAPT | |
| SCHEMBL1192669 | 0.66 | KDM4E (0.49) | PTGER4KDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL28301055 | 0.66 | SMN1; SMN2 (0.46) | KDM4EALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2294066-B9 | BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-03-11 | — | — | EP | disclosed |
| EP-2294066-B1 | BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-13 | — | — | EP | disclosed |