Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15938054 | 0.78 | SMN1; SMN2 (0.44) | KMT2AMEN1KDM4EPOLBMAPK1 | |
| SCHEMBL14862084 | 0.78 | SMN1; SMN2 (0.47) | HTTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL14862217 | 0.77 | KDM4E (0.48) | KMT2AMEN1KDM4EPOLBMAPK1 | |
| SCHEMBL14862371 | 0.75 | KDM4E (0.47) | HTTKMT2AMEN1KDM4EMAPK1 | |
| SCHEMBL14861647 | 0.75 | KMT2A (0.53) | KMT2AMEN1KDM4EPOLBMAPK1 | |
| SCHEMBL15937997 | 0.75 | KDM4E (0.41) | HTTKMT2AMEN1KDM4EGRIN2D | |
| SCHEMBL14861880 | 0.74 | ALDH1A1 (0.51) | HTTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL15937999 | 0.73 | MEN1 (0.50) | HTTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL14862128 | 0.73 | NOTUM (0.51) | HTTKMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL14862052 | 0.73 | HTT (0.49) | HTTKMT2AMEN1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745257-B2 | Phenyl-guanidine derivatives | UNIVERSIDAD NACIONAL DE QUILMES (AR) | 2017-08-29 | — | — | US | claimed |
| EP-2766342-B1 | PHENYL-GUANIDINE DERIVATIVES | UNIV NAC QUILMES (AR) | 2016-02-10 | — | — | EP | claimed |
| US-20140228388-A1 | Phenyl-Guanidine Derivatives | UNIVERSIDAD NACIONAL DE QUILMES (AR) | 2014-08-14 | — | — | US | claimed |
| US-9745257-B2 | Phenyl-guanidine derivatives | UNIVERSIDAD NACIONAL DE QUILMES (AR) | 2017-08-29 | — | — | US | disclosed |
| EP-2766342-B1 | PHENYL-GUANIDINE DERIVATIVES | UNIV NAC QUILMES (AR) | 2016-02-10 | — | — | EP | disclosed |
| US-20140228388-A1 | Phenyl-Guanidine Derivatives | UNIVERSIDAD NACIONAL DE QUILMES (AR) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228388-A1 | Phenyl-Guanidine Derivatives | RAPGEF3, ARHGDIA, G3BP1 | HTT 2935/4885KMT2A 3111/4885MEN1 3028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.