Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.36 |
| ▸ | TNNC1 | P63316 | 6/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.36 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.30 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15939326 | 0.90 | S1PR1 (0.37) | S1PR1TNNC1S1PR3S1PR4S1PR5 | |
| SCHEMBL15939479 | 0.85 | FFAR1 (0.36) | FFAR1CTSB | |
| SCHEMBL15939390 | 0.85 | S1PR1 (0.39) | S1PR1TNNC1S1PR3S1PR4S1PR5 | |
| SCHEMBL15939377 | 0.79 | ALDH1A1 (0.38) | FFAR1CTSB | |
| SCHEMBL15939401 | 0.77 | ACACB (0.35) | CTSB | |
| SCHEMBL9112789 | 0.74 | S1PR1 (0.48) | S1PR1GPR183FFAR1CTSB | |
| SCHEMBL9110086 | 0.72 | TNK2 (0.46) | S1PR1S1PR5 | |
| SCHEMBL9111763 | 0.72 | S1PR1 (0.51) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL9112164 | 0.71 | CTSB (0.32) | S1PR1CTSB | |
| SCHEMBL15939092 | 0.71 | ACACB (0.34) | S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014126932-A1 | ALKYNE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-08-21 | — | — | WO | claimed |
| US-20140228445-A1 | ALKYNE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-08-14 | — | — | US | claimed |
| WO-2014126932-A1 | ALKYNE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-08-21 | — | — | WO | disclosed |
| WO-2014126932-A1 | ALKYNE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-08-21 | — | — | WO | disclosed |
| US-20140228445-A1 | ALKYNE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-08-14 | — | — | US | disclosed |
| US-20140228445-A1 | ALKYNE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-08-14 | — | — | US | disclosed |
| US-20140228445-A1 | ALKYNE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228445-A1 | ALKYNE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885TNNC1 4518/4885S1PR3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.