SCHEMBL159406

SCHEMBL159406

Nc1ccc(-n2ccnc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 1.00
MAPT P10636 1/20 1.00
ENPP2 Q13822 1/20 0.64
MKNK1 Q9BUB5 1/20 0.64
MKNK2 Q9HBH9 1/20 0.64
NOTUM Q6P988 1/20 0.64
CYP3A4 P08684 4/20 0.63
MEN1 O00255 1/20 0.60
ALOX15 P16050 1/20 0.60
TSHR P16473 1/20 0.60
KMT2A Q03164 1/20 0.60
BAZ2B Q9UIF8 1/20 0.55
CYP51A1 Q16850 1/20 0.53
CYP2A6 P11509 1/20 0.52
CYP19A1 P11511 3/20 0.52
CYP11B1 P15538 2/20 0.52
CYP11B2 P19099 2/20 0.52
ADH5 P11766 1/20 0.51
CYP1A2 P05177 1/20 0.50
CYP2D6 P10635 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8339879 0.98 LMNA (0.96) LMNAMAPTENPP2MKNK1MKNK2
SCHEMBL28046795 0.98 LMNA (0.96) LMNAMAPTENPP2MKNK1MKNK2
Hydrochloric Acid SCHEMBL3565712 0.98 LMNA (0.96) LMNAMAPTENPP2MKNK1MKNK2
SCHEMBL28046704 0.98 LMNA (0.96) LMNAMAPTENPP2MKNK1MKNK2
SCHEMBL28046707 0.98 LMNA (0.96) LMNAMAPTENPP2MKNK1MKNK2
Hydrochloric Acid SCHEMBL28420692 0.98 LMNA (0.96) LMNAMAPTENPP2MKNK1MKNK2
SCHEMBL5836930 0.89 MAPT (0.79) LMNAMAPTENPP2MKNK1MKNK2
SCHEMBL10126954 0.89 LMNA (0.79) LMNAMAPTENPP2MKNK1MKNK2
SCHEMBL2532397 0.89 LMNA (0.78) LMNAMAPTENPP2MKNK1MKNK2
SCHEMBL6324509 0.86 MAPT (0.74) LMNAMAPTENPP2MKNK1MKNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 766 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250354045-A1 COOLING LIQUID AND COOLING SYSTEM INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2025-11-20 US claimed
WO-2025075506-A1 COATED POROUS MEDIA, METHOD OF MANUFACTURING A COATED POROUS MEDIA AND THE USE OF SUCH COATED POROUS MEDIA TECHNISCHE UNIVERSITEIT EINDHOVEN (NL) 2025-04-10 WO claimed
CN-118465091-A Method for enriching and detecting bisphenol based on ionic metal organic framework material 山东省分析测试中心 2024-08-09 CN claimed
CN-118272958-A Preparation method and application of high-strength cellulose-based composite fiber 界首市盛泰服装科技有限公司 2024-07-02 CN claimed
CN-118120908-A Method for separating and purifying melanoidin based on pH sensitive metal chelate precipitant, melanoidin and application thereof 天津现代创新中药科技有限公司 2024-06-04 CN claimed
CN-114349707-B N-substituted urea compound and preparation method and application thereof 中国医学科学院医药生物技术研究所 2024-01-09 CN claimed
CN-117258568-A Ionic super-crosslinked polymer film, preparation method and application thereof 南通斐腾新材料科技有限公司 2023-12-22 CN claimed
CN-111841611-B Noble metal monatomic catalyst and preparation method assisted by using notch polyacid 西北工业大学 2023-03-14 CN claimed
CN-111961091-B Imidazole derivative polybasic aromatic carboxylate iron complex and preparation method and application thereof 生态环境部南京环境科学研究所 2023-01-31 CN claimed
CN-114890991-A Preparation method and application of hyperbranched bifunctional polymerization ionic liquid catalyst 东南大学 2022-08-12 CN claimed
WO-2007121852-A2 LIGHTENING AND/OR COLOURING AGENTS COMPRISING AMIDINES HENKEL AG & CO. KGAA (DE) 2007-11-01 WO claimed
WO-2007121853-A2 LIGHTENING AND/OR COLOURING AGENTS COMPRISING N,N'-OXALYLDIAZOLES AND/OR OXIMIDYLDIAZOLES HENKEL AG & CO. KGAA (DE) 2007-11-01 WO claimed
WO-2007121851-A1 LIGHTENING AND/OR COLOURING AGENTS COMPRISING HALOGENATED KETONES HENKEL AG & CO. KGAA (DE) 2007-11-01 WO claimed
WO-2007118616-A1 BLEACHING AND/OR COLOURING AGENT WITH IMPROVED SKIN COMPATIBILITY HENKEL AG & CO. KGAA (DE) 2007-10-25 WO claimed
WO-2007096027-A1 BLEACHING AGENTS HENKEL AG & CO. KGAA (DE) 2007-08-30 WO claimed
EP-1773768-A2 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS Exelixis, Inc. (US) 2007-04-18 EP claimed
WO-2006012642-A2 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS, INC. (US) 2006-02-02 WO claimed
US-20050182050-A1 Therapeutic heterocyclic compounds ASTRAZENECA AB (SE) 2005-08-18 US claimed
US-6812225-B2 PYSCHOLOGICAL DISORDERS; ANTIDEPRESSANTS ASTRAZENECA AB (SE) 2004-11-02 US claimed
US-20030013708-A1 Therapeutic heterocyclic compounds ASTRAZENECA AB (SE) 2003-01-16 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050182050-A1 Therapeutic heterocyclic compounds HTR1B, HTR1D, HTR1A LMNA 1663/4885MAPT 653/4885ENPP2 668/4885
US-20030013708-A1 Therapeutic heterocyclic compounds HTR1A, HTR1D, HTR1B LMNA 1808/4885MAPT 661/4885ENPP2 866/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.