Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8957369 | 0.94 | KMT2A (0.61) | KMT2ANR4A2PLA2G4BKDM4ENR1H4 | |
| SCHEMBL9803295 | 0.86 | KMT2A (0.80) | KMT2ANR4A2PLA2G4BNR1H4POLB | |
| SCHEMBL4509654 | 0.84 | KMT2A (0.77) | KMT2ANR4A2PLA2G4BNR1H4PRSS1 | |
| SCHEMBL15941568 | 0.83 | TP53 (0.59) | PLA2G4BHTT | |
| SCHEMBL30167982 | 0.82 | KMT2A (0.80) | KMT2ANR4A2PLA2G4BNR1H4POLB | |
| SCHEMBL10787479 | 0.82 | KMT2A (0.80) | KMT2ANR4A2PLA2G4BNR1H4POLB | |
| SCHEMBL9402647 | 0.81 | KMT2A (0.73) | KMT2ANR4A2PLA2G4BNR1H4PRSS1 | |
| SCHEMBL3026943 | 0.80 | CA12 (0.59) | PLA2G4BHTT | |
| SCHEMBL9337589 | 0.80 | KMT2A (0.71) | KMT2ANR4A2PLA2G4BNR1H4POLB | |
| SCHEMBL6932542 | 0.79 | KMT2A (0.75) | KMT2ANR4A2PLA2G4BNR1H4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023555-B2 | NSAIDs derivatives and uses thereof | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2018-07-17 | — | — | US | disclosed |
| US-20150376162-A1 | NSAIDs DERIVATIVES AND USES THEREOF | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2015-12-31 | — | — | US | disclosed |
| EP-2953627-A1 | NSAIDs DERIVATIVES AND USES THEREOF | The Research Foundation of the City University of New York (US) | 2015-12-16 | — | — | EP | disclosed |
| WO-2014124208-A1 | NSAIDs DERIVATIVES AND USES THEREOF | THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2014-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023555-B2 | NSAIDs derivatives and uses thereof | PTGES, PTGES3, PTGS1 | KMT2A 4527/4885NR4A2 1463/4885PLA2G4B 313/4885 |
| US-20150376162-A1 | NSAIDs DERIVATIVES AND USES THEREOF | PTGES, PTGES3, PTGS1 | KMT2A 4527/4885NR4A2 1463/4885PLA2G4B 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.