Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.61 |
| ▸ | TDO2 | P48775 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | GABRP | O00591 | 1/20 | 0.61 |
| ▸ | GABRD | O14764 | 1/20 | 0.61 |
| ▸ | IKBKB | O14920 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | CHUK | O15111 | 1/20 | 0.61 |
| ▸ | TOP1 | P11387 | 1/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.61 |
| ▸ | IDO1 | P14902 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.61 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22810058 | 1.00 | PIM1 (0.61) | PIM1TDO2ALDH1A1ACHEKDM4E | |
| SCHEMBL29625633 | 0.89 | HASPIN (0.59) | PIM1ACHECHUKHASPINCCNT1 | |
| SCHEMBL9739332 | 0.86 | ACHE (0.57) | PIM1ACHEHASPINCCNT1CDK9 | |
| SCHEMBL31037120 | 0.82 | AHR (0.74) | ALDH1A1KDM4EHPGDAHRTOP2A | |
| SCHEMBL5716702 | 0.82 | AHR (0.74) | ALDH1A1KDM4EHPGDAHRTOP2A | |
| SCHEMBL29386574 | 0.82 | AHR (0.74) | ALDH1A1KDM4EHPGDAHRTOP2A | |
| SCHEMBL12886713 | 0.81 | HASPIN (0.51) | PIM1TDO2ALDH1A1ACHEKDM4E | |
| SCHEMBL11071687 | 0.81 | HASPIN (0.48) | PIM1ACHECHUKHASPINCCNT1 | |
| SCHEMBL17228830 | 0.80 | AHR (0.78) | ALDH1A1KDM4EHPGDAHRTOP2A | |
| SCHEMBL15073657 | 0.80 | AHR (0.77) | ALDH1A1KDM4EHPGDAHRTOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3352794-A1 | A SYNTHETIC LETHAL DRUG COMBINATION FOR TREATING RENAL CELL CARCINOMA | Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR) | 2018-08-01 | — | — | EP | claimed |
| WO-2017050842-A1 | A SYNTHETIC LETHAL DRUG COMBINATION FOR TREATING RENAL CELL CARCINOMA | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2017-03-30 | — | — | WO | claimed |
| US-20020160972-A1 | Compositions and methods for modulating RNA | ISIS PHARMACEUTICALS, INC. | 2002-10-31 | — | — | US | claimed |
| US-6358931-B1 | OLIGONUCLETIDE CONJUGATED TO IMIDAZOLE; INTERCALATION AND COORDINATION COMPOUNDS; MEDICAL DIAGNOSIS, GENE THERAPY; ANTISENSE AGENTS | ISIS PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | claimed |
| EP-0591058-B1 | Ellipticine derivatives with antitumor activity | ADIR (FR) | 1998-06-03 | — | — | EP | claimed |
| EP-0035244-B1 | CYCLOALKA(4,5)PYRROLO(2,3-G)ISOQUINOLINES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | claimed |
| US-4483989-A | BENZOYLATION 6-HYDROXYCARBAZOLE, FORMYLATING, CYCLIZATION, AND SAPONIFICATION | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (ANVAR) (FR) | 1984-11-20 | — | — | US | claimed |
| EP-0010029-B1 | ELLIPTICINES SUBSTITUTED IN POSITION 1 BY A POLYAMINE CHAIN, THEIR SYNTHESIS AND MEDICINES CONTAINING THEM | ANVAR Agence Nationale de Valorisation de la Recherche (FR) | 1982-11-17 | — | — | EP | claimed |
| EP-0010029-A2 | Ellipticines substituted in position 1 by a polyamine chain, their synthesis and medicines containing them | ANVAR Agence Nationale de Valorisation de la Recherche (FR) | 1980-04-16 | — | — | EP | claimed |
| EP-4210703-A1 | SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS | Expansion Therapeutics, Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| US-20220288100-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | IONIS PHARMACEUTICALS, INC. (US) | 2022-09-15 | — | — | US | disclosed |
| WO-2022055922-A1 | SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS | EXPANSION THERAPEUTICS, INC. (US) | 2022-03-17 | — | — | WO | disclosed |
| CN-111100123-B | A process for preparing ellipticine or substituted ellipticine | 中国医学科学院药物研究所 | 2021-08-13 | — | — | CN | disclosed |
| US-20200276222-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | IONIS PHARMACEUTICALS, INC. (US) | 2020-09-03 | — | — | US | disclosed |
| EP-0485636-A1 | INDOLE DERIVATIVE | TORAY INDUSTRIES, INC. (JP) | 1992-05-20 | — | — | EP | disclosed |
| EP-0035244-B1 | CYCLOALKA(4,5)PYRROLO(2,3-G)ISOQUINOLINES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |
| US-4483989-A | BENZOYLATION 6-HYDROXYCARBAZOLE, FORMYLATING, CYCLIZATION, AND SAPONIFICATION | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (ANVAR) (FR) | 1984-11-20 | — | — | US | disclosed |
| US-4434290-A | TREATMENT OF LEUKEMIAS | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (FR) | 1984-02-28 | — | — | US | disclosed |
| EP-0010029-B1 | ELLIPTICINES SUBSTITUTED IN POSITION 1 BY A POLYAMINE CHAIN, THEIR SYNTHESIS AND MEDICINES CONTAINING THEM | ANVAR Agence Nationale de Valorisation de la Recherche (FR) | 1982-11-17 | — | — | EP | disclosed |
| EP-0010029-A2 | Ellipticines substituted in position 1 by a polyamine chain, their synthesis and medicines containing them | ANVAR Agence Nationale de Valorisation de la Recherche (FR) | 1980-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020160972-A1 | Compositions and methods for modulating RNA | RNGTT, NSUN3, NSUN2 | PIM1 2794/4885TDO2 4054/4885ALDH1A1 2561/4885 |
| US-20200276222-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | NSUN2, SNRPE, RBM3 | PIM1 3818/4885TDO2 3223/4885ALDH1A1 4411/4885 |
| US-20220288100-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | NSUN2, SNRPE, RBM3 | PIM1 3818/4885TDO2 3223/4885ALDH1A1 4411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.