Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.57 |
| ▸ | HASPIN | Q8TF76 | 10/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.53 |
| ▸ | CDK9 | P50750 | 4/20 | 0.53 |
| ▸ | PIM1 | P11309 | 3/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29625633 | 0.93 | HASPIN (0.59) | ACHEHASPINCCNT1CDK9PIM1 | |
| SCHEMBL22810058 | 0.86 | PIM1 (0.61) | ACHEHASPINCCNT1CDK9PIM1 | |
| SCHEMBL1594417 | 0.86 | PIM1 (0.61) | ACHEHASPINCCNT1CDK9PIM1 | |
| SCHEMBL11071687 | 0.83 | HASPIN (0.48) | ACHEHASPINCCNT1CDK9PIM1 | |
| SCHEMBL24277019 | 0.81 | ACHE (0.73) | ACHEHASPINCCNT1CDK9PIM1 | |
| SCHEMBL29642993 | 0.80 | ACHE (0.78) | ACHEPIM1KIF11MAPTPARP1 | |
| SCHEMBL972999 | 0.80 | ACHE (0.78) | ACHEPIM1KIF11MAPTPARP1 | |
| SCHEMBL12886713 | 0.77 | HASPIN (0.51) | ACHEHASPINCCNT1CDK9PIM1 | |
| SCHEMBL19335578 | 0.76 | ACHE (0.50) | ACHEPIM1KIF11MAPTPARP1 | |
| SCHEMBL11064167 | 0.75 | HASPIN (0.46) | HASPINCCNT1CDK9PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2292222-A | — | — | None | — | — | JP | disclosed |
| EP-2440547-B1 | New chemical molecules that inhibit the splicing mechanism for the treatment of diseases resulting from splicing defects | ABIVAX (FR) | 2022-11-30 | — | — | EP | disclosed |
| CN-113501785-A | Method for constructing amino isoquinoline derivatives through transition metal catalyzed C-H activation/cyclization reaction | 四川大学 | 2021-10-15 | — | — | CN | disclosed |
| US-5079363-A | From an alkoxypyridine and an indole derivative, antitumor and antileukemia agents | SANOFI (FR) | 1992-01-07 | — | — | US | disclosed |
| JP-H02292222-A | USE OF DIPYRIDO(4,3-B)(3,4-F)INDOLE FOR PREPARING MEDICINE USEFUL FOR TREATMENT OF AIDS | INST NATL SANTE & RECH MED <INSERM> | 1990-12-03 | — | — | JP | disclosed |
| EP-0394112-A2 | Use of dipyrido(4,3-b)(3,4-f) indoles for the preparation of medicaments for the treatment of AIDS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1990-10-24 | — | — | EP | disclosed |
| EP-0394112-A2 | Use of dipyrido(4,3-b)(3,4-f) indoles for the preparation of medicaments for the treatment of AIDS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1990-10-24 | — | — | EP | disclosed |
| EP-0334695-A1 | Process for the preparation of isoquinoline derivatives | ELF SANOFI (FR) | 1989-09-27 | — | — | EP | disclosed |
| US-4444776-A | ANTITUMOR, ANTIVIRAL | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (A N V A R) (FR) | 1984-04-24 | — | — | US | disclosed |